Description

Guanosine 5'-Monophosphate, Diammonium Salt, [8-14C] is a radiolabeled nucleotide derivative where the carbon-14 isotope is specifically incorporated at the 8-position of the guanine base. This product is essential for precise metabolic and enzymatic pathway tracing in biochemical research. It is primarily used by scientists and R&D professionals in the pharmaceutical, biotechnology, and life science sectors for advanced studies in nucleotide metabolism, RNA synthesis, and drug discovery.

Application

• Tracer Studies in Nucleotide Metabolism: Used to investigate the biosynthesis, catabolism, and salvage pathways of guanine nucleotides within cells.
• Enzyme Kinetics & Mechanism Research: Serves as a labeled substrate for studying the activity and inhibition of key enzymes like GMP kinases and nucleotidyltransferases.
• RNA Synthesis & Processing Research: Enables the study of RNA transcription, capping, and processing mechanisms by tracing the incorporation of labeled GMP.
• Drug Discovery & Development: Utilized in ADME (Absorption, Distribution, Metabolism, Excretion) studies for nucleotide-based therapeutics and antivirals.
• Biochemical Assay Development: Acts as a critical component in developing sensitive radiometric assays for high-throughput screening.
• Metabolic Flux Analysis: Applied in systems biology to model and quantify fluxes through purine metabolic networks.

Basic Information

Product Name	Guanosine 5'-Monophosphate, Diammonium Salt, [8-14C]
CAS No.	336804-74-1
Molecular Formula	C10H19N7O8P * (NH4)2 (¹⁴C labeled)
Molecular Weight	Contact for details
Synonyms	8-¹⁴C-GMP Diammonium Salt; [8-14C]GMP Diammonium Salt; Guanosine-5'-monophosphoric acid diammonium salt (8-14C); 5'-GMP-(NH4)2 [8-14C]; 8-Carbon-14 labeled GMP diammonium; Guanylic acid diammonium salt (8-14C); 5'-Guanylic acid, diammonium salt, [8-14C]; Radiolabeled GMP diammonium salt
EINECS	Contact for details

Quality Control

Every batch of our radiolabeled compounds is produced and analyzed under stringent quality protocols. The product undergoes rigorous testing to ensure high radiochemical purity and specific activity as specified. Analytical methods include HPLC with radiometric detection and spectroscopic techniques. A comprehensive Certificate of Analysis (COA), detailing radiochemical purity, chemical purity, specific activity, and solvent composition, is provided with each shipment to ensure traceability and compliance with research standards.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). For long-term storage, keep the primary container in a sealed secondary container with desiccant. Follow all applicable laboratory safety and radiation safety guidelines for handling and disposal.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Radiochemical Purity (HPLC)	≥ 97%
Chemical Purity (HPLC)	≥ 95%
Specific Activity	50-60 mCi/mmol (Contact for exact value)
Solvent (for solutions)	Specified aqueous or buffer solution
Radionuclidic Purity	≥ 99% Carbon-14

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.