Description

R-2,2'-Dihydroxy-α,α,α',α'-Tetraphenyl-[1,1'-Binaphthalene]-3,3'-Dimethanol is a sophisticated chiral ligand and building block of significant importance in asymmetric synthesis. Its value lies in its ability to induce high enantioselectivity in catalytic reactions, which is critical for producing single-enantiomer pharmaceuticals and fine chemicals. This compound is essential for R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors who require precise stereochemical control.

Application

• As a chiral ligand for transition metal catalysts in asymmetric hydrogenation, C-C bond formation, and other enantioselective transformations.
• As a key precursor or intermediate in the synthesis of more complex chiral auxiliaries and organocatalysts.
• In the research and development of active pharmaceutical ingredients (APIs) where specific chirality is required for biological activity.
• For the synthesis of chiral stationary phases used in high-performance liquid chromatography (HPLC) for enantiomer separation.
• In academic and industrial research focused on developing novel catalytic systems and exploring new asymmetric methodologies.
• As a building block for functional materials with potential applications in sensors or nonlinear optics due to its rigid, conjugated structure.

Basic Information

Product Name	R-2,2'-Dihydroxy-α,α,α',α'-Tetraphenyl-[1,1'-Binaphthalene]-3,3'-Dimethanol
CAS No.	336185-31-0
Molecular Formula	C46H34O4
Molecular Weight	650.76 g/mol
Synonyms	(R)-VAPOL; (R)-2,2'-Diphenyl-3,3'-(hydroxydiphenylmethyl)-1,1'-binaphthalene-2,2'-diol; (R)-2,2'-Bis(diphenylhydroxymethyl)-1,1'-binaphthyl; VAPOL ligand; (R)-VAPOL ligand; R-VAPOL; (R)-VAPOL alcohol; (R)-2,2'-Bis(α,α-diphenyl-2-pyridylmethoxy)-1,1'-binaphthyl (common precursor name)
EINECS	Contact for details

Quality Control

Our production of R-2,2'-Dihydroxy-α,α,α',α'-Tetraphenyl-[1,1'-Binaphthalene]-3,3'-Dimethanol adheres to stringent quality protocols to ensure batch-to-batch consistency and high chiral purity, which is paramount for catalytic performance. Each lot is characterized by advanced analytical techniques including HPLC, NMR, and optical rotation measurement. A comprehensive Certificate of Analysis (COA) detailing identity, purity, enantiomeric excess, and physical properties is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container should be kept in a desiccated environment to prevent degradation. Handle and store under an inert atmosphere for long-term stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (ee)	≥ 99.0%
Specific Rotation [α]D20	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.