Description

trans-3,4,5-Trifluorocinnamic Acid is a high-purity fluorinated cinnamic acid derivative, distinguished by its unique trifluoromethyl substitution pattern. This compound serves as a critical advanced pharmaceutical intermediate and versatile building block for the synthesis of complex molecules. It is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and material science sectors who require precise fluorination to modulate the biological activity and physical properties of their target compounds.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in drug discovery programs targeting CNS disorders, inflammation, and oncology.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and pesticides, where the fluorine atoms enhance bioavailability and environmental stability.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorinated liquid crystals and organic light-emitting diode (OLED) materials, improving electronic properties and device performance.
• Peptide Mimetics & Bio-conjugation: The carboxylic acid group enables its use in creating fluorinated peptide analogs and for bio-conjugation applications in medicinal chemistry.
• Cross-Coupling Reactions: An excellent substrate for Suzuki, Heck, and other palladium-catalyzed cross-coupling reactions to construct complex biaryl systems.
• Academic & Industrial R&D: A valuable reagent for research in synthetic organic chemistry, fluorochemistry, and material science.

Basic Information

Product Name	trans-3,4,5-Trifluorocinnamic Acid
CAS No.	331245-88-6
Molecular Formula	C9H5F3O2
Molecular Weight	202.13 g/mol
Synonyms	(E)-3-(3,4,5-Trifluorophenyl)acrylic acid; 3,4,5-Trifluorocinnamic Acid; trans-3-(3,4,5-Trifluorophenyl)-2-propenoic acid; (2E)-3-(3,4,5-Trifluorophenyl)prop-2-enoic acid; 3,4,5-Trifluorocinammic Acid; 3,4,5-Trifluoro-trans-cinnamic Acid
EINECS	Contact for details

Quality Control

Our trans-3,4,5-Trifluorocinnamic Acid is manufactured under a strict quality management system. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high chemical purity and structural integrity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliable supply and batch-to-batch consistency for your critical R&D and production needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); the container must be kept tightly sealed in a dry environment to prevent degradation. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.