Description

5(S)-Hete-D8 is a deuterium-labeled analog of the eicosanoid 5(S)-HETE, a key metabolite in the arachidonic acid cascade. This stable isotope-labeled compound is essential for use as an internal standard in quantitative mass spectrometry-based analytical methods. It is primarily utilized by researchers and quality control laboratories in the pharmaceutical, biotechnology, and clinical diagnostics sectors for precise lipidomic profiling, metabolic pathway studies, and biomarker validation.

Application

• Internal Standard for LC-MS/MS: Serves as a critical quantitative reference standard in liquid chromatography-tandem mass spectrometry (LC-MS/MS) for the accurate measurement of endogenous 5(S)-HETE levels in biological matrices.
• Biomarker Research: Enables precise investigation of 5(S)-HETE's role as a biomarker in inflammatory diseases, cancer research, and cardiovascular studies.
• Drug Metabolism & Pharmacokinetics (DMPK): Used in pharmaceutical development to study the metabolism of drugs targeting the lipoxygenase pathway.
• Clinical Diagnostics: Supports the development and validation of high-sensitivity clinical assays for eicosanoid profiling.
• Lipidomics: A vital tool in comprehensive lipidomics studies to understand lipid mediator networks and their biological functions.

Basic Information

Product Name	5(S)-Hete-D8
CAS No.	330796-62-8
Molecular Formula	C₂₀H₂₄D₈O₃
Molecular Weight	328.5 g/mol (approx.)
Synonyms	5(S)-Hydroxyeicosatetraenoic acid-d8; (5S)-HETE-d8; 5(S)-HETE-d8; 5S-HETE-d8; [5,6,8,9,11,12,14,15-²H₈]-5(S)-HETE; Deuterated 5(S)-HETE; 5(S)-HETE Internal Standard
EINECS	Contact for details

Quality Control

Every batch of 5(S)-Hete-D8 is manufactured and analyzed under strict quality protocols to ensure the highest standards of isotopic purity and chemical identity required for analytical applications. Our quality assurance includes comprehensive testing via NMR, HPLC, and mass spectrometry. A detailed Certificate of Analysis (COA) providing batch-specific data on purity, isotopic enrichment, and solvent content is supplied with each product to support your regulatory and research requirements.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below under an inert atmosphere. Allow the sealed vial to equilibrate to room temperature before opening to prevent moisture condensation. Store away from strong oxidizers.

Specification

Item	Specification
Appearance	Colorless to pale yellow oil or film
Identification (NMR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95% (Chemical Purity)
Isotopic Enrichment	≥ 98 atom % D
Solvent Content (Residual Solvent)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.