Description

1,2-Dipalmitoyl-D62-Sn-Glycero-3-Phosphoethanolamine is a deuterium-labeled phospholipid, specifically a perdeuterated dipalmitoylphosphatidylethanolamine (DPPE-d62). This compound is a critical tool in advanced biophysical research, offering unique spectroscopic properties due to its deuterated acyl chains. It is primarily utilized by researchers in academia and the pharmaceutical industry who require precise, non-perturbing molecular probes for studying membrane dynamics, structure, and protein-lipid interactions. The high isotopic purity and defined structure make it indispensable for techniques like NMR spectroscopy, neutron scattering, and mass spectrometry.

Application

• Membrane Biophysics Research: As a key component in constructing model lipid bilayers and vesicles for studying membrane fluidity, phase transitions, and lateral organization.
• NMR Spectroscopy: Used as a deuterated probe in 2H-NMR studies to elucidate molecular order and dynamics within lipid membranes without isotopic interference.
• Neutron Scattering Studies: Essential for contrast variation experiments in small-angle neutron scattering (SANS) to determine the structure and thickness of lipid bilayers.
• Lipidomics & Mass Spectrometry: Serves as a high-purity internal standard or reference compound for the quantitative analysis of phosphatidylethanolamine species in complex biological samples.
• Drug Delivery System Development: Incorporated into liposomal formulations to study the stability, release kinetics, and targeting efficiency of encapsulated therapeutics.
• Protein-Lipid Interaction Studies: Used to investigate the binding and functional modulation of membrane-associated proteins and peptides within a defined lipid environment.

Basic Information

Product Name	1,2-Dipalmitoyl-D62-Sn-Glycero-3-Phosphoethanolamine
CAS No.	326495-42-5
Molecular Formula	C37D62NO8P
Molecular Weight	~734.4 g/mol (for deuterated form)
Synonyms	DPPE-d62; 1,2-Dihexadecanoyl-D62-sn-glycero-3-phosphoethanolamine; Deuterated DPPE; Perdeuterated Dipalmitoylphosphatidylethanolamine; DPPE (d62); Phosphatidylethanolamine-d62 (16:0/16:0); PE(16:0/16:0)-d62; (2R)-2,3-Bis(hexadecanoyloxy)propyl (2-aminoethyl) hydrogen phosphate (d62)
EINECS	Contact for details

Quality Control

Every batch of 1,2-Dipalmitoyl-D62-Sn-Glycero-3-Phosphoethanolamine is produced and analyzed under strict quality protocols to ensure the highest isotopic and chemical purity for research applications. Our quality commitment includes comprehensive analytical characterization. Certificates of Analysis (COA) are provided with each shipment, detailing key parameters such as isotopic enrichment, chemical purity, and absence of critical impurities.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to minimize oxidation and hydrolysis. The product is hygroscopic (moisture-sensitive) and easily oxidized; allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid or waxy solid
Identification (NMR)	Conforms to structure
Isotopic Enrichment (Deuterium)	≥ 98 atom % D
Purity (HPLC)	≥ 95%
Solubility	Soluble in chloroform, methanol, ethanol; forms liposomes in aqueous buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.