Description

(S)-Bupropion Hydrochloride CAS NO 324548-45-0 is the single enantiomer form of the hydrochloride salt of bupropion, a well-known aminoketone-class compound. This high-purity chiral intermediate is critical for the development and manufacturing of enantiomerically pure active pharmaceutical ingredients (APIs). It is primarily required by pharmaceutical R&D laboratories and production facilities focused on advanced neurological and psychiatric therapeutics, where the specific stereochemistry can influence pharmacological activity and metabolic profile.

Application

• Key chiral intermediate in the synthesis of enantiomerically pure pharmaceutical active ingredients (APIs).
• Research and development of novel central nervous system (CNS) drugs targeting depression and smoking cessation.
• Preclinical and clinical studies investigating the distinct pharmacokinetic and pharmacodynamic properties of the (S)-enantiomer.
• Production of reference standards and impurities for analytical method development and quality control.
• Manufacturing of advanced pharmaceutical formulations requiring specific stereochemical control.
• Building block in organic synthesis for creating more complex chiral molecules.

Basic Information

Product Name	(S)-Bupropion Hydrochloride
CAS No.	324548-45-0
Molecular Formula	C13H19Cl2NO
Molecular Weight	276.20 g/mol
Synonyms	(S)-2-(tert-Butylamino)-1-(3-chlorophenyl)propan-1-one hydrochloride; (S)-Bupropion HCl; (S)-Amfebutamone Hydrochloride; (S)-1-(3-Chlorophenyl)-2-[(1,1-dimethylethyl)amino]-1-propanone hydrochloride; (S)-TBUP HCl; (S)-BW 323U hydrochloride; (2S)-2-(tert-Butylamino)-3'-chloropropiophenone hydrochloride
EINECS	Contact for details

Quality Control

Our (S)-Bupropion Hydrochloride is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including chiral purity verification, to ensure it meets the stringent requirements for pharmaceutical intermediates. We provide full traceability and support regulatory filings. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available for every lot.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under dry, inert conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.5%
Chiral Purity (Enantiomeric Excess)	≥99.0%
Related Substances (HPLC)	Total impurities ≤1.5%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.