Description

Bupropion (S)-Isomer is the single enantiomer form of the widely used antidepressant and smoking cessation aid, bupropion. This specific stereoisomer is of significant interest in pharmaceutical research and development for studying structure-activity relationships and developing novel therapeutic agents. It serves as a critical chiral intermediate and reference standard for analytical and pharmacological studies. This high-purity material is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and fine chemical sectors.

Application

• Pharmaceutical Reference Standard: Used as a certified standard for analytical method development, validation, and quality control (QC/QA) in API manufacturing.
• Chiral Intermediate: Serves as a key building block in the enantioselective synthesis of novel active pharmaceutical ingredients (APIs) and investigational drugs.
• Metabolite Studies: Employed in pharmacokinetic and metabolic pathway research to understand the biological activity and clearance of the (S)-enantiomer.
• Pharmacological Research: Critical for in-vitro and in-vivo studies aimed at elucidating the distinct biological profile and receptor binding affinity of the (S)-isomer.
• Impurity Profiling: Used to identify, quantify, and control the (S)-enantiomer as a potential impurity in the production of racemic bupropion or its (R)-isomer.
• Regulatory Submissions: Provides essential data and materials for regulatory filings (e.g., with FDA, EMA) requiring enantiomer-specific information.

Basic Information

Product Name	Bupropion (S)-Isomer
CAS No.	324548-43-8
Molecular Formula	C13H18ClNO
Molecular Weight	239.74 g/mol
Synonyms	(S)-Bupropion; (2S)-2-(tert-Butylamino)-1-(3-chlorophenyl)propan-1-one; (S)-2-(tert-Butylamino)-3'-chloropropiophenone; (S)-Amfebutamone; S-Bupropion; (S)-1-(3-Chlorophenyl)-2-[(1,1-dimethylethyl)amino]-1-propanone; BW 323U (S-isomer); Zyban (S-enantiomer)
EINECS	Contact for details

Quality Control

Our Bupropion (S)-Isomer is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral HPLC for enantiomeric excess (ee) determination, to ensure high chemical and optical purity suitable for research and development applications. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.