Description

([15N]Gly)-Glutathione (Reduced) is a stable isotope-labeled form of the essential cellular antioxidant, glutathione, where the glycine residue is enriched with the 15N isotope. This compound is critical for metabolic and pharmacokinetic studies, enabling precise tracking and quantification of glutathione pathways using mass spectrometry. It is primarily needed by researchers and manufacturers in the fields of pharmaceutical development, clinical diagnostics, and advanced biochemical research.

Application

• Isotope Dilution Mass Spectrometry (IDMS): Serves as an internal standard for the accurate quantification of endogenous glutathione levels in biological samples (e.g., plasma, tissues, cells).
• Metabolic Flux Analysis: Used to trace and model the dynamics of glutathione synthesis, utilization, and redox cycling in metabolic studies.
• Drug Metabolism & Pharmacokinetics (DMPK): Enables the study of drug-induced changes in glutathione metabolism and the role of glutathione in drug conjugation (e.g., with acetaminophen).
• Clinical Research: Investigates biomarkers of oxidative stress in diseases such as cancer, neurodegenerative disorders, and cardiovascular conditions.
• Nutritional Science: Studies the bioavailability and metabolic fate of glutathione and its precursors from dietary supplements.
• Quality Control Reference Standard: Acts as a certified reference material for the calibration of analytical instruments and validation of assay methods in diagnostic kits.

Basic Information

Product Name	([15N]Gly)-Glutathione (Reduced)
CAS No.	320374-87-6
Molecular Formula	C10H1715N3O6S
Molecular Weight	308.33 g/mol (for 15N1 isotopologue)
Synonyms	L-γ-Glutamyl-L-([15N]glycyl)-L-cysteine; γ-L-Glutamyl-L-([15N]glycyl)-L-cysteine; GSH-15N (Gly); Reduced Glutathione-15N (Gly); (Glycine-15N)Glutathione; L-Glutathione reduced (Glycine-15N); Isotope Labeled Glutathione; 15N1-Gly-Glutathione
EINECS	Contact for details

Quality Control

Our ([15N]Gly)-Glutathione (Reduced) is produced under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high chemical purity, isotopic enrichment, and stability. Specifications are verified by techniques including HPLC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA), detailing purity, isotopic purity (atom % 15N), and analytical data, is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to minimize oxidation and hydrolysis. For long-term storage, desiccate to protect against moisture. Allow the product to equilibrate to room temperature in a desiccator before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Isotopic Purity (Atom % 15N)	≥ 98%
Water Content (KF)	≤ 2.0%
Reduced Form (Assay)	≥ 90%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.