Description

(4R)-2-[2-(Diphenylphosphino)Phenyl]-4,5-Dihydro-4-(Phenylmethyl)-Oxazole is a high-value, chiral P,N-ligand widely used in asymmetric catalysis. Its core value lies in enabling highly enantioselective transformations, which are critical for producing single-isomer intermediates in pharmaceutical and fine chemical synthesis. This product is essential for R&D chemists and process engineers in the pharmaceutical, agrochemical, and specialty chemical industries who require precise stereochemical control.

Application

• As a chiral ligand for asymmetric hydrogenation reactions, particularly for synthesizing enantiomerically pure amino acid derivatives and pharmaceutical intermediates.
• Catalyst component in asymmetric C-C bond-forming reactions, such as Heck couplings and allylic alkylations.
• Key reagent in the synthesis of complex natural products and active pharmaceutical ingredients (APIs) requiring high enantiomeric excess (ee).
• Used in academic and industrial research for developing new catalytic methodologies in organic synthesis.
• Employed in the production of chiral agrochemicals and flavors & fragrances.
• Facilitates stereoselective transformations in process chemistry for scale-up and manufacturing.

Basic Information

Product Name	(4R)-2-[2-(Diphenylphosphino)Phenyl]-4,5-Dihydro-4-(Phenylmethyl)-Oxazole
CAS No.	314020-70-7
Molecular Formula	C28H24NOP
Molecular Weight	421.47 g/mol
Synonyms	(R)-2-[2-(Diphenylphosphino)phenyl]-4,5-dihydro-4-(phenylmethyl)oxazole; (R)-2-[2-(Diphenylphosphino)phenyl]-4-benzyl-4,5-dihydrooxazole; (R)-4-Benzyl-2-[2-(diphenylphosphino)phenyl]-4,5-dihydrooxazole; (R)-PHOX Ligand; (R)-2-(2-Diphenylphosphinophenyl)-4-benzyl-4,5-dihydrooxazole; (4R)-4-Benzyl-2-[2-(diphenylphosphanyl)phenyl]-4,5-dihydro-1,3-oxazole; (R)-2-(2-Diphenylphosphinophenyl)-4-benzyl-2-oxazoline
EINECS	Contact for details

Quality Control

Our (4R)-2-[2-(Diphenylphosphino)Phenyl]-4,5-Dihydro-4-(Phenylmethyl)-Oxazole is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC for enantiomeric purity and NMR for structural confirmation, to ensure compliance with high-purity standards for research and catalysis. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and chiral purity is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at 2-8°C or as specified on the label or COA. This compound is easily oxidized and light-sensitive. Keep container tightly sealed in a dry and well-ventilated place.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Melting Point	Contact for details
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.