Description

2-Fluoro-4-Methoxy-5-Nitrobenzoic Acid Methyl Ester is a high-purity fluorinated aromatic building block of significant interest in advanced organic synthesis. This compound matters for its role as a key intermediate in the development of complex molecules, particularly in the pharmaceutical and agrochemical sectors. It is primarily needed by R&D chemists and process development scientists working on active pharmaceutical ingredients (APIs), specialty agrochemicals, and advanced material science applications.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of novel drug candidates, especially those targeting specific enzyme pathways where the fluorine atom and nitro group are essential for bioactivity.
• Agrochemical Synthesis: Used in the research and development of next-generation herbicides, fungicides, and pesticides, leveraging its unique substitution pattern.
• Material Science Research: Serves as a monomer or functionalizing agent in the creation of specialty polymers and liquid crystals with tailored electronic properties.
• Organic Synthesis Building Block: Employed in cross-coupling reactions, nucleophilic aromatic substitutions, and reduction reactions to construct more complex fluorinated aromatic systems.
• Dye and Pigment Intermediate: Utilized in the development of specialized dyes and pigments where the nitro and methoxy groups contribute to color and stability.

Basic Information

Product Name	2-Fluoro-4-Methoxy-5-Nitrobenzoic Acid Methyl Ester
CAS No.	313533-91-4
Molecular Formula	C9H8FNO5
Molecular Weight	229.16 g/mol
Synonyms	Methyl 2-Fluoro-4-Methoxy-5-Nitrobenzoate; 5-Nitro-2-Fluoro-4-Methoxybenzoic Acid Methyl Ester; Benzoic acid, 2-fluoro-4-methoxy-5-nitro-, methyl ester; Methyl 5-Nitro-2-Fluoro-4-Methoxybenzoate; 2-Fluoro-4-methoxy-5-nitro-benzoic acid methyl ester
EINECS	Contact for details

Quality Control

Our 2-Fluoro-4-Methoxy-5-Nitrobenzoic Acid Methyl Ester is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications and test results. Our quality commitment supports compliance with cGMP and ICH guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to prevent oxidation and moisture absorption. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.