Description

L-Alanine (U-13C3; 15N) is a high-purity, isotopically labeled derivative of the essential amino acid L-Alanine, where all three carbon atoms are uniformly labeled with carbon-13 and the nitrogen atom is labeled with nitrogen-15. This compound is critical for advanced research requiring precise metabolic pathway tracing and quantification using Nuclear Magnetic Resonance (NMR) and Mass Spectrometry (MS) techniques. It is primarily utilized by researchers and manufacturers in the fields of pharmaceutical development, metabolic studies, and stable isotope labeling for proteomics and biomarker discovery.

Application

• Metabolic Flux Analysis (MFA): As a tracer for studying central carbon metabolism in cell cultures, bacteria, and animal models.
• Pharmaceutical Research: Synthesis of isotopically labeled drug candidates and metabolites for pharmacokinetic and pharmacodynamic studies.
• Proteomics & Biomarker Discovery: Used in Stable Isotope Labeling by Amino acids in Cell culture (SILAC) for accurate protein quantification.
• NMR Spectroscopy: Serves as an internal standard or reference compound for structural and dynamic studies of biomolecules.
• Nutritional Science: Research into amino acid metabolism, protein synthesis, and turnover in nutritional studies.
• Diagnostic Agent Development: Potential precursor for developing advanced diagnostic imaging agents.

Basic Information

Product Name	L-Alanine (U-13C3; 15N)
CAS No.	312623-85-1
Molecular Formula	¹³C₃H₇¹⁵NO₂
Molecular Weight	92.06 (based on ¹³C=13.0034, ¹⁵N=15.0001)
Synonyms	(2S)-2-Azaniumyl-3-(¹³C)propanoate (¹⁵N); L-α-¹⁵N-Amino(¹³C₃)propionic Acid; (S)-2-Amino(¹³C₃)propionic-¹⁵N Acid; U-¹³C₃,¹⁵N-L-Alanine; Alanine-¹³C₃,¹⁵N; Isotopically Labeled L-Alanine; Stable Isotope Labeled Alanine
EINECS	Contact for details

Quality Control

Every batch of L-Alanine (U-13C3; 15N) is produced and analyzed under strict quality management protocols to ensure exceptional isotopic and chemical purity. Our products undergo rigorous testing, including NMR, HPLC, and MS analysis, to confirm isotopic enrichment, chiral purity, and absence of contaminants. A comprehensive Certificate of Analysis (COA) detailing isotopic purity (atom % ¹³C and ¹⁵N), chemical purity, and specific analytical data is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a cool, dry place. This material is hygroscopic (moisture-sensitive). For long-term storage, consider desiccant or inert atmosphere to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (¹³C)	≥ 99 atom % ¹³C
Isotopic Purity (¹⁵N)	≥ 98 atom % ¹⁵N
Optical Rotation	[α]²⁰D = +13.5° to +15.5° (c=1 in H₂O)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.