Description

(R)-(+)-5,5',6,6',7,7',8,8'-Octahydro-1,1'-Bi-2-Naphthol CAS NO 39648-74-3 is a high-purity, enantiomerically pure chiral ligand and building block of significant importance in asymmetric synthesis. Its rigid, C2-symmetric binaphthol structure makes it a highly effective catalyst and resolving agent for inducing chirality in pharmaceutical intermediates and fine chemicals. This compound is essential for research and production facilities in the pharmaceutical, agrochemical, and advanced materials sectors that require precise stereochemical control.

Application

• Asymmetric Catalysis: As a privileged chiral ligand for transition metal catalysts (e.g., with B, Ti, Al) in enantioselective reactions including hydrogenation, Diels-Alder, and alkylation.
• Pharmaceutical Intermediate Synthesis: A key chiral auxiliary in the production of enantiomerically pure active pharmaceutical ingredients (APIs) and drug candidates.
• Chiral Resolution: Used to separate racemic mixtures of alcohols, amines, and other compounds via diastereomeric salt formation or chromatography.
• Material Science: Serves as a monomer or dopant for creating chiral polymers, liquid crystals, and nonlinear optical materials with specific helical structures.
• Agrochemical Synthesis: Employed in the development of enantiomerically pure herbicides, fungicides, and pesticides for enhanced efficacy and environmental safety.
• Academic & Industrial R&D: A fundamental tool for methodological development in organic chemistry and process optimization in pilot plants.

Basic Information

Item	Detail
Product Name	(R)-(+)-5,5',6,6',7,7',8,8'-Octahydro-1,1'-Bi-2-Naphthol
CAS No.	39648-74-3
Molecular Formula	C20H22O2
Molecular Weight	294.39 g/mol
Synonyms	(R)-(+)-H8-BINOL; (R)-Octahydro-1,1'-bi-2-naphthol; (R)-5,5',6,6',7,7',8,8'-Octahydro-1,1'-binaphthyl-2,2'-diol; (R)-H8BINOL; (R)-1,1'-Bi-2-naphthol, octahydro-; (R)-(+)-Perhydro-1,1'-binaphthyl-2,2'-diol; (R)-Octahydrobinaphthol; (R)-H8-BINOL ligand
EINECS	Contact for details

Quality Control

Our (R)-H8-BINOL is manufactured under strict quality management systems to ensure batch-to-batch consistency and high enantiomeric purity. Quality is verified through a comprehensive suite of analytical techniques including HPLC, chiral HPLC, and 1H/13C NMR to confirm chemical and optical purity. A detailed Certificate of Analysis (COA) documenting identity, assay, enantiomeric excess (ee), and impurity profile is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The compound is light-sensitive and should be handled under an inert atmosphere for long-term storage to prevent potential oxidation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0% ee
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.