Description

Methyl (4S)-trans-2,2,5-Trimethyl-1,3-Dioxolane-4-Carboxylate is a high-purity chiral building block and protected form of glyceraldehyde. This compound matters for its role as a versatile intermediate in the stereoselective synthesis of complex organic molecules, offering precise control over three-dimensional structure. It is primarily needed by research chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for applications ranging from drug discovery to the production of natural products.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of nucleoside analogs, antiviral agents, and other active pharmaceutical ingredients (APIs) requiring specific stereochemistry.
• Agrochemical Synthesis: Used in the production of chiral pesticides and herbicides where the biological activity is highly dependent on the stereoisomer.
• Natural Product Synthesis: Serves as a starting material or intermediate in the total synthesis of complex natural products like sugars, macrolides, and other bioactive compounds.
• Asymmetric Catalysis & Ligand Development: Employed as a precursor for chiral ligands and catalysts used in enantioselective transformations.
• Fine Chemical Manufacturing: A valuable building block for creating specialty chemicals with defined stereocenters for advanced material science and electronics.
• Academic & Industrial R&D: A critical reagent for methodological development in organic chemistry and for exploring new synthetic pathways.

Basic Information

Product Name	Methyl (4S)-trans-2,2,5-Trimethyl-1,3-Dioxolane-4-Carboxylate
CAS No.	38410-80-9
Molecular Formula	C9H16O4
Molecular Weight	188.22 g/mol
Synonyms	(4S)-trans-2,2,5-Trimethyl-1,3-dioxolane-4-carboxylic acid methyl ester; (4S-cis)-2,2,5-Trimethyl-1,3-dioxolane-4-carboxylic Acid Methyl Ester; Methyl (4S)-2,2,5-Trimethyl-1,3-dioxolane-4-carboxylate; L-Glyceraldehyde Acetonide Methyl Ester; (S)-(-)-2,3-O-Isopropylidene-D-glyceraldehyde Methyl Ester; (S)-2,2-Dimethyl-1,3-dioxolane-4-carboxaldehyde, Methyl Ester; A Chiral Dioxolane Derivative
EINECS	Contact for details

Quality Control

Our Methyl (4S)-trans-2,2,5-Trimethyl-1,3-Dioxolane-4-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity assessment by HPLC, to ensure compliance with exacting standards for research and process chemistry. Certificates of Analysis (COA) detailing identity, purity, and enantiomeric excess are provided with every shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This compound is stable under standard conditions but should be kept away from strong acids and oxidizing agents. For long-term storage, consider inert atmosphere handling to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Specific Rotation [α]	Contact for details
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.