Description

D-Proline, 1,5-Dimethyl-, Methyl Ester, (5R)-Rel- (9Ci) is a high-purity, non-natural proline derivative characterized by its specific stereochemistry and functional groups. This compound serves as a critical chiral building block and intermediate in advanced organic synthesis, enabling the construction of complex molecules with precise stereocontrol. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs), peptide mimetics, and other fine chemicals where stereochemical integrity is paramount.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of novel therapeutic agents, particularly for protease inhibitors and other targeted therapies.
• Peptidomimetics & Constrained Peptides: Used to introduce conformational constraints and enhance metabolic stability in peptide-based drug design.
• Asymmetric Synthesis: Employed as a chiral auxiliary or ligand precursor in catalytic asymmetric reactions to induce enantioselectivity.
• Chemical Biology & Proteomics: Acts as a specialized probe or building block for studying enzyme mechanisms and protein-protein interactions.
• Agrochemical Research: Utilized in the synthesis of chiral active ingredients for crop protection products.
• Academic & Industrial R&D: Serves as a valuable reagent for methodological development in organic chemistry and medicinal chemistry programs.

Basic Information

Product Name	D-Proline, 1,5-Dimethyl-, Methyl Ester, (5R)-Rel- (9Ci)
CAS No.	38228-17-0
Molecular Formula	C8H15NO2
Molecular Weight	157.21 g/mol
Synonyms	(5R)-1,5-Dimethyl-L-proline methyl ester; Methyl (5R)-1,5-dimethyl-L-prolinate; Methyl (2S,5R)-1,5-dimethylpyrrolidine-2-carboxylate; (R)-1,5-Dimethylproline methyl ester; D-1,5-Dimethylproline methyl ester; (5R)-rel-1,5-Dimethylproline methyl ester; L-Proline, 1,5-dimethyl-, methyl ester, (5R)-rel-
EINECS	Contact for details

Quality Control

Our D-Proline, 1,5-Dimethyl-, Methyl Ester, (5R)-Rel- (9Ci) is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity assessment by HPLC, to ensure it meets the high standards required for research and pharmaceutical applications. A detailed Certificate of Analysis (COA) providing identity, purity, and impurity profiles is supplied with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.