Description

D-Alanine, [1-14C] is a high-purity, carbon-14 labeled isotopologue of the non-proteinogenic amino acid D-alanine. This radiochemical is essential for advanced metabolic and biochemical research, providing a critical tracer for studying amino acid metabolism, enzyme mechanisms, and peptide synthesis pathways. It is primarily utilized by pharmaceutical R&D teams, academic research institutions, and CROs specializing in isotope-labeled compound synthesis and tracer studies.

Application

• Metabolic Pathway Tracing: Used as a radiolabeled tracer to investigate the metabolism and fate of D-alanine in biological systems.
• Enzyme Kinetics & Mechanism Studies: Employed in research on enzymes like D-amino acid oxidase (DAAO) and alanine racemase to elucidate reaction mechanisms and kinetics.
• Peptide & Antibiotic Biosynthesis Research: Serves as a labeled precursor in studies of non-ribosomal peptide synthesis, particularly relevant for antibiotics like vancomycin that incorporate D-alanine.
• Pharmaceutical ADME Studies: Applied in Absorption, Distribution, Metabolism, and Excretion (ADME) research for drug candidates that interact with D-amino acid pathways.
• Biochemical Probe Development: Utilized in the synthesis of labeled probes for binding assays and diagnostic research.
• Microbiological Research: Used to study bacterial cell wall synthesis, as D-alanine is a key component of peptidoglycan.

Basic Information

Product Name	D-Alanine, [1-14C]
CAS No.	38062-88-3
Molecular Formula	C3H714CNO2
Molecular Weight	Contact for details
Synonyms	(R)-2-Amino[1-14C]propanoic acid; D-2-Aminopropionic acid-1-14C; (R)-Alanine-1-14C; D-α-Alanine-1-14C; (R)-2-Aminopropanoic acid-1-14C; D-Alanine-1-Carbon-14; [1-14C]-D-Alanine
EINECS	Contact for details

Quality Control

Our radiochemicals are produced and handled under strict quality control protocols to ensure high specific activity and radiochemical purity. Each batch is analyzed via HPLC with radiometric detection to confirm identity and purity. Comprehensive Certificates of Analysis (COA) detailing specific activity, radiochemical purity, chemical purity, and solvent composition are provided with every shipment to ensure traceability and compliance with research standards.

Storage

Preserve in a tightly closed container, protected from light. Store at or below -20°C. This product is hygroscopic (moisture-sensitive) and must be stored in a dry environment. For long-term storage, keep the container sealed under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Radiochemical Purity (HPLC)	≥ 98%
Chemical Purity (HPLC)	≥ 95%
Specific Activity	Contact for details
Solvent (if supplied in solution)	Specified on COA

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.