Description

Serotonin Binoxalate, 5-[2-14C] is a radiolabeled derivative of the critical neurotransmitter serotonin, specifically labeled with carbon-14 at the 5-position. This compound is essential for advanced biochemical and pharmacological research, enabling precise metabolic and receptor binding studies. It is primarily utilized by research institutions, pharmaceutical R&D departments, and contract research organizations (CROs) focused on neuroscience, drug discovery, and tracer methodology.

Application

• Metabolic Pathway Tracing: Used as a radiotracer to study the biosynthesis, degradation, and metabolic fate of serotonin in biological systems.
• Receptor Binding Assays: Critical for in vitro and ex vivo studies to quantify serotonin receptor (5-HT receptor) density, affinity, and occupancy.
• Neuropharmacology Research: Facilitates the investigation of psychotropic drugs, antidepressants, and anxiolytics that target the serotonergic system.
• Autoradiography: Enables the visualization and spatial mapping of serotonin uptake sites and receptors in tissue sections.
• ADME (Absorption, Distribution, Metabolism, Excretion) Studies: Employed in preclinical drug development to track the pharmacokinetics of novel compounds interacting with serotonin pathways.
• Enzyme Activity Studies: Serves as a substrate for studying enzymes involved in serotonin metabolism, such as monoamine oxidase (MAO).

Basic Information

Item	Detail
Product Name	Serotonin Binoxalate, 5-[2-14C]
CAS No.	37960-18-2
Molecular Formula	C₁₂H₁₄N₂O₆ * ¹⁴CH₂O₂
Molecular Weight	Contact for details
Synonyms	5-Hydroxytryptamine Binoxalate, 5-[2-14C]; 5-HT-[2-14C] Binoxalate; 3-(2-Aminoethyl)-1H-indol-5-ol Binoxalate (14C-labeled); Serotonin Hydrogen Oxalate, Radiolabeled; 5-[2-14C]Serotonin Oxalate; Enteramine Binoxalate (14C); Thrombocytin Binoxalate, Labeled
EINECS	Contact for details

Quality Control

Every batch of our radiolabeled Serotonin Binoxalate is manufactured and tested under strict quality systems. We ensure high radiochemical purity and specific activity through advanced analytical techniques including HPLC with radiometric detection. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing radionuclidic purity, chemical purity, specific activity, and solvent composition. Our quality commitment supports compliance with GLP (Good Laboratory Practice) standards for research applications.

Storage

Preserve in a tightly closed container, protected from light. Store at or below -20°C. This product is hygroscopic (moisture-sensitive) and light-sensitive. For long-term storage, keep the container sealed under an inert atmosphere in a dedicated freezer. Allow the vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC, MS)	Conforms to reference standard
Radiochemical Purity (HPLC)	≥ 97%
Specific Activity	50-60 mCi/mmol (Contact for exact value)
Chemical Purity (HPLC)	≥ 95%
Solvent (for solution forms)	Ethanol:Water (Specified on COA)
Concentration	1.0 mCi/mL ± 10% (or as specified)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.