Description

Hemoglobin Hammersmith is a well-characterized variant of human hemoglobin, a critical oxygen-transporting protein. This specific mutant, identified by the CAS number 37359-23-2, is of significant value for biochemical research and diagnostic development due to its altered oxygen-binding properties. It serves as an essential reference standard and research tool for scientists in hematology, clinical diagnostics, and biopharmaceutical sectors studying hemoglobinopathies and oxygen transport dynamics.

Application

• Biochemical Research: Used as a model protein for studying the structure-function relationship of hemoglobin, particularly oxygen affinity and allosteric regulation.
• Diagnostic Standard: Serves as a calibrated reference material in the development and validation of clinical assays for detecting abnormal hemoglobins.
• Hematology Studies: Essential for in-vitro studies investigating the pathophysiology of thalassemias and other hemoglobin-based disorders.
• Pharmaceutical Development: Acts as a research tool in drug discovery programs targeting sickle cell disease and conditions related to oxygen delivery.
• Educational & Calibration: Used in academic and industrial laboratories for method calibration and as a teaching aid for advanced biochemistry.

Basic Information

Product Name	Hemoglobin Hammersmith
CAS No.	37359-23-2
Molecular Formula	C2952H4664N812O840S16Fe4 (Human HbA approximate)
Molecular Weight	~64,500 Da (Tetramer)
Synonyms	Hemoglobin Hammersmith (β42(CD1)Phe→Ser); Hb Hammersmith; Hemoglobin variant Hammersmith; Unstable hemoglobin Hammersmith; HBB: c.128T>C; β42 Phe→Ser mutant hemoglobin; Hemoglobin β-chain mutant Phe-42-Ser; Deoxyhemoglobin Hammersmith (if applicable).
EINECS	Contact for details

Quality Control

Our Hemoglobin Hammersmith is produced and handled under stringent quality protocols to ensure batch-to-batch consistency and reliability for critical research. Each lot is subjected to comprehensive analytical characterization. Certificates of Analysis (COA) are provided, detailing parameters such as purity (by HPLC), spectral properties, and functional activity. We adhere to relevant guidelines for research-grade biological materials to support your scientific integrity.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store frozen at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake. Aliquot into single-use vials to avoid repeated freeze-thaw cycles.

Specification

Item	Specification
Appearance	Lyophilized powder or solution
Identification (UV-Vis)	Conforms to characteristic spectrum of hemoglobin
Purity (HPLC)	≥ 95% (Hemoglobin Hammersmith variant)
Assay (Functional)	Oxygen-binding capacity confirmed
Solubility	Clear solution in appropriate buffer
Endotoxin	< 1.0 EU/mg (where specified)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.