Description

L-Proline-(4-3H(N)) CAS NO 37159-97-0 is a high-specific-activity tritium-labeled derivative of the essential amino acid L-proline, designed for advanced research applications. This radiolabeled compound is critical for precise metabolic and pharmacokinetic studies, enabling researchers to track biochemical pathways with high sensitivity. It is primarily utilized by pharmaceutical R&D teams, academic research institutions, and contract research organizations (CROs) specializing in drug discovery and biochemical analysis.

Application

• Tracer Studies in Metabolism Research: Used to investigate proline metabolism, collagen biosynthesis, and related biochemical pathways in vivo and in vitro.
• Drug Discovery & Development: Serves as a key tool in ADME (Absorption, Distribution, Metabolism, Excretion) studies for candidate drugs targeting amino acid transporters or metabolic enzymes.
• Biochemical & Enzymatic Assays: Employed as a substrate or tracer in enzyme activity assays and mechanistic studies of proline-utilizing enzymes.
• Receptor Binding & Uptake Studies: Facilitates research into amino acid transport systems and receptor-ligand interactions within the central nervous system and other tissues.
• Nutritional & Biomedical Research: Applied in studies examining protein synthesis, wound healing, and cellular stress responses where proline plays a vital role.
• Quality Control & Reference Standard: Can be used as an internal standard or reference material in analytical method development for proline quantification.

Basic Information

Item	Details
Product Name	L-Proline-(4-3H(N))
CAS No.	37159-97-0
Molecular Formula	C₅H₇TNO₂
Molecular Weight	~118.1 g/mol (Calculated for unlabeled form C5H9NO2)
Synonyms	(2S)-Pyrrolidine-2-carboxylic-4-3H acid; L-2-Pyrrolidinecarboxylic-4-3H acid; L-Proline-4-3H; Tritiated L-Proline; [4-3H]-L-Proline; Proline, L- (tritiated); (S)-(-)-Proline-4-3H; 4-Tritio-L-proline
EINECS	Contact for details

Quality Control

Every batch of our L-Proline-(4-3H(N)) is manufactured and tested under stringent quality systems to ensure exceptional purity and specific activity. We provide comprehensive Certificates of Analysis (COA) that detail radionuclidic purity, radiochemical purity (typically >97% by HPLC), specific activity, and chemical purity. Our quality commitment aligns with cGMP principles for research chemicals, ensuring reliability and consistency for critical studies.

Storage

Preserve in a tightly closed container, protected from light. Store at or below -20°C in the original solvent as supplied. For long-term storage, keep at -70°C to -80°C. The product is light-sensitive (store away from light). Appropriate shielding and handling procedures for radioactive materials must be followed in accordance with local and international regulations.

Specification

Item	Specification
Appearance	Clear, colorless to slightly yellow solution
Identification (HPLC)	Conforms to reference standard
Radiochemical Purity (HPLC)	≥ 97%
Specific Activity	Contact for details (Ci/mmol range)
Chemical Purity (HPLC)	≥ 95%
Solvent	Ethanol:Water mixture (specified on label)
Concentration	1 mCi/mL (Nominal)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.