Description

Levosimendan is a calcium sensitizer and vasodilator belonging to the pyridazinone-dinitrile class of compounds. Its primary value lies in its inotropic and vasodilatory effects, making it a critical active pharmaceutical ingredient (API) for the treatment of acute decompensated heart failure. This compound is essential for pharmaceutical manufacturers and research institutions developing cardiology medications. The product is supplied as Levosimendan CAS NO 36725-41-4, meeting the stringent quality requirements for advanced pharmaceutical synthesis.

Application

• Pharmaceutical API: Primary use as the active ingredient in injectable formulations for the treatment of acute decompensated heart failure.
• Cardiology Drug Development: Key intermediate or reference standard in R&D for new heart failure therapies and combination drugs.
• Clinical Research: Used in preclinical and clinical studies to investigate mechanisms of cardiac contractility and vasodilation.
• Generic Drug Manufacturing: Sourcing for the production of generic versions of branded heart failure medications.
• Biochemical Research: Tool compound for studying calcium sensitization in cardiac muscle and vascular smooth muscle cells.

Basic Information

Product Name	Levosimendan
CAS No.	36725-41-4
Molecular Formula	C14H12N6O
Molecular Weight	280.28 g/mol
Synonyms	(-)-[[4-(1,4,5,6-Tetrahydro-4-methyl-6-oxo-3-pyridazinyl)phenyl]hydrazono]propanedinitrile; (R)-(-)-[[4-(1,4,5,6-Tetrahydro-4-methyl-6-oxo-3-pyridazinyl)phenyl]hydrazono]propanedinitrile; Simdax (trade name); OR-1259
EINECS	Contact for details

Quality Control

Our Levosimendan is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identification by IR and NMR spectroscopy, and stringent control of related substances and residual solvents. We provide full traceability and Certificates of Analysis (COA) are available for all shipments, ensuring compliance with ICH guidelines and current Good Manufacturing Practice (cGMP) standards for pharmaceutical ingredients.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	Yellow to orange crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Water (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Specific Rotation	-115° to -125° (c=1 in DMSO)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.