Description

H-[15N]Tyr-Oh is a stable isotope-labeled derivative of the amino acid L-Tyrosine, specifically enriched with Nitrogen-15 at the amino position. This high-purity labeled compound is essential for advanced research requiring precise metabolic and proteomic tracing. It is primarily utilized by scientists and manufacturers in the fields of pharmaceutical research, nuclear magnetic resonance (NMR) spectroscopy, and mass spectrometry-based quantitative analysis.

Application

• Metabolic Pathway Tracing: Used as a labeled precursor in studies of protein synthesis, degradation, and amino acid metabolism.
• Quantitative Proteomics & Biomarker Discovery: Serves as an internal standard for accurate mass spectrometry (MS) quantification in SILAC (Stable Isotope Labeling by Amino acids in Cell culture) and related methodologies.
• NMR Spectroscopy Studies: Provides a non-radioactive tracer for investigating molecular structure, dynamics, and interactions in complex biological systems.
• Pharmaceutical R&D: Employed in the development and testing of new drugs, particularly in pharmacokinetic and metabolic stability studies.
• Nutritional Research: Applied in studies examining protein turnover, amino acid requirements, and metabolic disorders.
• Chemical Reference Standard: Acts as a certified reference material for analytical method development and validation in quality control laboratories.

Basic Information

Product Name	H-[15N]Tyr-Oh
CAS No.	35424-81-8
Molecular Formula	C9H10[15N]NO3
Molecular Weight	182.18 g/mol (for [15N] labeled form)
Synonyms	L-Tyrosine-[15N]; (2S)-2-Amino-3-(4-hydroxyphenyl)[15N]propanoic acid; [15N]-L-Tyrosine; Tyrosine-15N; 15N-L-Tyr; 15N Labeled L-Tyrosine; H-Tyr(15N)-OH; 15N Amino Acid Standard
EINECS	Contact for details

Quality Control

Every batch of H-[15N]Tyr-Oh is manufactured and tested under strict quality management systems. We guarantee high chemical and isotopic purity, with comprehensive testing including HPLC for chemical purity, NMR and MS for isotopic enrichment verification, and specific optical rotation. Certificates of Analysis (COA) detailing all specifications and test results are provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment	≥ 98 atom % 15N
Specific Optical Rotation	-10.0° to -12.0° (c=1 in 1N HCl)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.