Description

Tenofovir is a potent nucleotide reverse transcriptase inhibitor (NRTI) that serves as a critical active pharmaceutical ingredient (API) in antiviral therapies. Its primary value lies in its efficacy against HIV-1 and Hepatitis B viruses, forming the backbone of several globally prescribed antiretroviral regimens. This high-purity compound is essential for pharmaceutical manufacturers developing and producing solid oral dosage forms, such as tablets and capsules. Consistent quality and reliable supply of this API are paramount for ensuring the safety and effectiveness of the final medicinal products.

Application

• Pharmaceutical Active Ingredient: Primary use as the API in antiretroviral drugs for the treatment of HIV-1 infection.
• Hepatitis B Medication: Key component in antiviral therapies specifically targeting chronic Hepatitis B virus (HBV).
• Fixed-Dose Combination Drugs: Used in combination with other antiretroviral agents (e.g., emtricitabine, efavirenz) in single-tablet regimens.
• Generic Drug Manufacturing: Sourcing for the production of bioequivalent generic versions of branded antiretroviral medications.
• Pre-Exposure Prophylaxis (PrEP): API for medications used in HIV prevention strategies.
• Research & Development: Reference standard and building block in virology research and the development of new antiviral compounds.
• Pharmaceutical Intermediates: Serves as a key intermediate for the synthesis of prodrug forms like tenofovir disoproxil fumarate (TDF) and tenofovir alafenamide (TAF).

Basic Information

Product Name	Tenofovir
CAS No.	34956-22-4
Molecular Formula	C9H14N5O4P
Molecular Weight	287.21 g/mol
Synonyms	PMPA; (R)-9-(2-Phosphonomethoxypropyl)adenine; (R)-PMPA; GS 1278; 9-[(R)-2-(Phosphonomethoxy)propyl]adenine; Adefovir diphosphate analog; Bis(POC)PMPA precursor; Tenofovir free acid
EINECS	Contact for details

Quality Control

Our Tenofovir is manufactured under strict quality management systems to ensure it meets the rigorous standards required for pharmaceutical applications. Each batch is subjected to comprehensive analytical testing, including identification, assay, and impurity profile analysis via validated methods such as HPLC. We provide full traceability and support regulatory submissions with detailed documentation. Certificates of Analysis (COA) are available for every batch, confirming compliance with in-house specifications aligned with major pharmacopoeial standards (e.g., USP, EP).

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to minimize exposure to atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual impurity: ≤ 0.5% Total impurities: ≤ 1.5%
Specific Rotation	-12.0° to -14.0° (c=1 in H2O)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.