Description

3-Hydroxy-3-Methylglutaric Anhydride is a versatile cyclic anhydride derivative of 3-hydroxy-3-methylglutaric acid, serving as a key chiral building block and reactive intermediate in advanced organic synthesis. Its value lies in its bifunctional reactivity, allowing for ring-opening reactions and subsequent derivatization to create complex molecular architectures. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries, particularly for developing active pharmaceutical ingredients (APIs) and fine chemicals.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of statin-class cholesterol-lowering drugs (e.g., HMG-CoA reductase inhibitors) and other bioactive molecules.
• Chiral Building Block: Utilized in asymmetric synthesis to introduce stereogenic centers, essential for creating enantiomerically pure compounds.
• Polymer Chemistry: Acts as a monomer or cross-linking agent for producing specialty polyesters, polyanhydrides, and other functional polymers.
• Agrochemical Synthesis: Employed in the development of advanced herbicides, fungicides, and plant growth regulators.
• Bioconjugation & Linker Chemistry: Useful for modifying biomolecules, peptides, or creating cleavable linkers in drug delivery systems.
• Fine Chemical Production: Serves as an intermediate for flavors, fragrances, and other high-value specialty chemicals.
• Academic & R&D: A valuable reagent for methodological development and exploring new synthetic pathways in organic chemistry.

Basic Information

Product Name	3-Hydroxy-3-Methylglutaric Anhydride
CAS No.	34021-48-2
Molecular Formula	C6H8O4
Molecular Weight	144.13 g/mol
Synonyms	3-Hydroxy-3-methylglutaric acid anhydride; 3-Hydroxy-3-methylpentanedioic anhydride; HMG Anhydride; 3-Methyl-3-hydroxypentanedioic anhydride; (3-Hydroxy-3-methyl-1,5-dioxolan-4-one); 3-Hydroxy-3-methylglutaric acid cyclic anhydride; 3-Hydroxy-3-methylglutaryl anhydride
EINECS	Contact for details

Quality Control

Our 3-Hydroxy-3-Methylglutaric Anhydride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and chiral purity analysis, to ensure it meets the high standards required for research and industrial synthesis. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions to prevent hydrolysis. For long-term storage, consider using a desiccator or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity	Contact for details
Water Content (KF)	≤ 0.5%
Melting Point	Contact for details
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.