Description

Boc-Val-Anhydride is a high-purity, protected amino acid derivative essential for peptide synthesis. This compound serves as a critical building block, enabling the controlled introduction of the valine amino acid residue while protecting the amine group from unwanted side reactions. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of novel peptides, APIs, and complex organic molecules.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key reagent for the sequential coupling of valine in automated and manual peptide assembly.
• Solution-Phase Peptide Synthesis: Used in classical peptide chain elongation strategies for research-scale and industrial production.
• Pharmaceutical Intermediate: Serves as a precursor in the synthesis of peptide-based active pharmaceutical ingredients (APIs) and drug candidates.
• Bioconjugation & Labeling: Facilitates the site-specific modification of peptides and proteins for diagnostic or therapeutic applications.
• Organic Synthesis Building Block: Employed in the construction of non-peptide compounds requiring a protected valine moiety.
• Research & Development: Essential for academic and industrial R&D focused on peptide chemistry, medicinal chemistry, and biochemistry.

Basic Information

Product Name	Boc-Val-Anhydride
CAS No.	33294-55-2
Molecular Formula	C₁₂H₂₁NO₅
Molecular Weight	259.30 g/mol
Synonyms	N-(tert-Butoxycarbonyl)-L-valine Anhydride; Boc-L-Valine Anhydride; (S)-2-((tert-Butoxycarbonyl)amino)-3-methylbutanoic Anhydride; N-Boc-L-valine Anhydride; tert-Butyloxycarbonylvaline Anhydride; Boc-Val-ON; Boc-Val-O-N; N-(tert-Butyloxycarbonyl)valine Anhydride
EINECS	Contact for details

Quality Control

Our Boc-Val-Anhydride is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot is subjected to comprehensive analytical testing, including HPLC for assay and chiral purity, and IR for structural confirmation. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere such as nitrogen or argon.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Optical Rotation [α]²⁰D	-15.0° to -18.0° (c=1 in CHCl₃)
Chiral Purity (HPLC)	≥ 99.0% (L-isomer)
Melting Point	78°C - 82°C
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.