Description

Adenosine-8-3H is a tritium-labeled derivative of adenosine, a fundamental nucleoside in biochemistry. This radiolabeled compound is essential for high-sensitivity detection and quantification in metabolic and enzymatic studies. It is primarily utilized by researchers and scientists in the pharmaceutical, biotechnology, and academic sectors for advanced tracer applications, including receptor binding assays, nucleotide transport studies, and metabolic pathway analysis.

Application

• Biochemical Tracer Studies: Used to trace and quantify adenosine uptake, metabolism, and incorporation into nucleic acids.
• Receptor Binding Assays: Critical for studying adenosine receptor (A1, A2A, A2B, A3) affinity, density, and pharmacological characterization.
• Enzyme Kinetics Research: Employed as a substrate for enzymes like adenosine deaminase, nucleoside kinases, and S-adenosylhomocysteine hydrolase.
• Metabolic Pathway Analysis: Investigates purine salvage pathways, ATP synthesis, and intracellular signaling mechanisms.
• Drug Discovery & Development: Supports screening and mechanistic studies for cardiovascular, anti-inflammatory, and neurological therapeutics.
• Molecular Imaging Probes: Serves as a precursor for developing targeted imaging agents in preclinical research.

Basic Information

Product Name	Adenosine-8-3H
CAS No.	32603-44-4
Molecular Formula	C₁₀H₁₂N₅O₄ (³H)
Molecular Weight	Contact for details
Synonyms	8-Tritioadenosine; [8-³H]Adenosine; Adenosine-8-³H; 9-β-D-Ribofuranosyladenine-8-³H; 6-Amino-9-β-D-ribofuranosyl-9H-purine-8-³H; Tritiated Adenosine (8-position); ³H-Adenosine (8-³H)
EINECS	Contact for details

Quality Control

Every batch of Adenosine-8-3H is manufactured and analyzed under strict quality systems to ensure exceptional radiochemical purity and specific activity. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) detailing radiochemical purity, specific activity, and solvent composition are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in the original solvent as supplied. For long-term storage, keep at -70°C to -80°C. The product is light-sensitive and should be handled in accordance with laboratory safety protocols for radioactive materials. Avoid exposure to strong acids and organic solvents.

Specification

Item	Specification
Appearance	Clear, colorless to slightly yellow solution
Identification (HPLC)	Conforms to reference standard
Radiochemical Purity (HPLC)	≥ 95%
Specific Activity	10-40 Ci/mmol (Contact for specific value)
Chemical Purity (HPLC)	≥ 98%
Solvent	Ethanol:Water (Specific ratio available on COA)
Concentration	1 mCi/mL (Nominal)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.