Description

n-(Guanin-8-Yl)-2-Aminofluorene is a specialized heterocyclic aromatic amine derivative, recognized for its role as a critical reference standard and research chemical. This compound is of significant importance in analytical chemistry and toxicology for the study of DNA adducts and mutagenic processes. It is primarily required by research institutions, pharmaceutical development laboratories, and analytical service providers engaged in genetic toxicology, carcinogenesis research, and method validation.

Application

• DNA Adduct Research: Serves as a crucial analytical standard for the identification and quantification of specific DNA lesions formed by aromatic amine exposure.
• Mutagenicity and Carcinogenicity Studies: Used as a reference compound in in vitro and in vivo assays to understand the mechanisms of chemical-induced genotoxicity.
• Analytical Method Development: Employed as a high-purity calibrant in advanced chromatographic (HPLC, LC-MS) and spectroscopic techniques for method validation.
• Biomarker Analysis: Facilitates research into biological monitoring by providing a definitive standard for metabolite or adduct detection in complex matrices.
• Toxicological Reference Material: Provides a certified material for quality control in laboratories conducting safety assessments for regulatory submissions.
• Academic and Pharmaceutical R&D: Supports fundamental research in chemical biology, medicinal chemistry, and the development of chemopreventive agents.

Basic Information

Product Name	n-(Guanin-8-Yl)-2-Aminofluorene
CAS No.	32366-79-3
Molecular Formula	C19H14N6O
Molecular Weight	342.35 g/mol
Synonyms	8-(2-Aminofluoren-9-yl)guanine; N-(9H-Guanin-8-yl)-9H-fluoren-2-amine; 2-Aminofluorene-guanine adduct; AF-Gua; Guanine-C8-2-aminofluorene; N2-(2-Aminofluoren-9-yl)-guanine; DNA Adduct Standard (AF-G)
EINECS	Contact for details

Quality Control

Our n-(Guanin-8-Yl)-2-Aminofluorene is manufactured under strict quality protocols to ensure the high purity and consistency required for research and analytical applications. Each batch is characterized using advanced analytical techniques including NMR, HPLC, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment, supporting compliance with GLP and ISO 17025 standards where applicable.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term storage, consider storing desiccated at -20°C. Handle with appropriate personal protective equipment in a well-ventilated laboratory setting.

Specification

Item	Specification
Appearance	Off-white to light yellow solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.