Description

(-)-trans-1,2-Cyclohexanedicarboxylic Anhydride is a high-purity, chiral cyclic anhydride of significant interest in advanced organic synthesis and materials science. Its value lies in its role as a versatile building block for introducing the rigid, stereodefined trans-1,2-cyclohexane moiety into target molecules. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and specialty polymer industries, where it is used to create chiral intermediates, ligands, and functional materials with specific three-dimensional architectures.

Application

• Pharmaceutical Intermediate: A key chiral precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for drugs requiring a rigid, stereochemically defined core structure.
• Agrochemical Synthesis: Used in the development of chiral herbicides, fungicides, and plant growth regulators where the specific spatial orientation of the molecule is critical for bioactivity.
• Asymmetric Catalyst & Ligand Development: Serves as a foundational scaffold for constructing novel chiral ligands and organocatalysts used in enantioselective transformations.
• Specialty Polymer & Resin Modifier: Incorporated into polymer backbones (e.g., epoxy resins, polyimides, polyesters) to impart rigidity, thermal stability, and specific optical properties.
• Fine Chemical & Flavor/Fragrance Intermediate: Employed in the multi-step synthesis of complex natural product analogs and aroma chemicals.
• Academic & R&D: A valuable reagent for methodological development in organic chemistry and materials science research.

Basic Information

Product Name	(-)-trans-1,2-Cyclohexanedicarboxylic Anhydride
CAS No.	31982-85-1
Molecular Formula	C8H10O3
Molecular Weight	154.16 g/mol
Synonyms	(-)-trans-Cyclohexane-1,2-dicarboxylic anhydride; (1R,2R)-Cyclohexane-1,2-dicarboxylic anhydride; (R,R)-1,2-Cyclohexanedicarboxylic anhydride; trans-Hexahydrophthalic anhydride (specific enantiomer); L-trans-1,2-Cyclohexanedicarboxylic acid anhydride; (1R,2R)-Hexahydrophthalic anhydride; Chiral trans-cyclohexane-1,2-dicarboxylic anhydride; (R,R)-HHPA
EINECS	Contact for details

Quality Control

Our (-)-trans-1,2-Cyclohexanedicarboxylic Anhydride is manufactured under strict quality control protocols to ensure high chemical and enantiomeric purity, meeting the stringent requirements of research and industrial applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing key parameters such as assay, enantiomeric excess (e.e.), and impurity profiles. We adhere to cGMP principles where applicable, and our quality systems are designed to ensure traceability, consistency, and reliability for our global B2B clients.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to prevent moisture absorption, which can lead to hydrolysis. Keep away from strong bases, strong oxidizing agents, and sources of heat.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0% e.e.
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.