Description

A-Methyldigoxin is a potent, semi-synthetic cardiac glycoside derived from digoxin, offering a distinct pharmacological profile. This high-purity compound is critical for pharmaceutical research and development, particularly in cardiovascular studies. It serves as a key reference standard and active pharmaceutical ingredient (API) intermediate for manufacturers and research institutions globally.

Application

• Pharmaceutical Reference Standard: Used for the calibration of analytical instruments and validation of assay methods in quality control laboratories.
• Active Pharmaceutical Ingredient (API) Intermediate: A crucial building block in the synthesis of specialized cardiac medications.
• Biochemical Research: Employed in studies investigating the mechanism of action of cardiac glycosides on sodium-potassium ATPase pumps.
• Pharmacokinetic & Metabolic Studies: Utilized to understand the absorption, distribution, metabolism, and excretion profiles of digoxin analogs.
• Formulation Development: Aids in the development and testing of new drug delivery systems for heart failure treatments.
• Clinical Trial Material (CTM): Sourced for the production of materials used in preclinical and clinical research phases.

Basic Information

Product Name	A-Methyldigoxin
CAS No.	31962-94-4
Molecular Formula	C42H66O14
Molecular Weight	794.97 g/mol
Synonyms	Methyldigoxin; Medigoxin; β-Methyldigoxin; Lanitop; Digicor; Metildigossina; 4''-O-Methyldigoxin; 16β-[(2R,4S,5S,6R)-5-Methyl-4,6-dihydroxyoxan-2-yl]oxy-12β,14-dihydroxy-5β-card-20(22)-enolide
EINECS	Contact for details

Quality Control

Our A-Methyldigoxin is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation, to ensure it meets exacting standards for pharmaceutical research. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting full compliance with specified parameters.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a desiccated environment to maintain stability and potency.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.