Description

Bupropion Hydrochloride is a hydrochloride salt of the aminoketone class, widely recognized for its role as an active pharmaceutical ingredient (API). Its primary commercial value lies in its application as a key intermediate in the synthesis of antidepressant and smoking cessation medications. This compound is essential for manufacturers in the global pharmaceutical industry, particularly those specializing in central nervous system (CNS) therapeutics. Consistent quality and reliable supply are critical for ensuring the efficacy and safety of the final drug products.

Application

• Pharmaceutical Active Ingredient (API): Primary use as the active component in antidepressant formulations.
• Smoking Cessation Aid: Key intermediate in the manufacture of medications designed to reduce nicotine cravings and withdrawal symptoms.
• Generic Drug Manufacturing: Sourcing for the production of cost-effective generic versions of branded CNS drugs.
• Research & Development: Utilized in preclinical and clinical studies for developing new therapeutic agents targeting depression and addiction.
• Reference Standard: Serves as a high-purity standard for quality control and analytical testing in pharmaceutical laboratories.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for large-scale API synthesis.

Basic Information

Product Name	Bupropion Hydrochloride
CAS No.	31677-93-7
Molecular Formula	C13H18ClNO • HCl
Molecular Weight	276.21 g/mol
Synonyms	Amfebutamone Hydrochloride; (±)-Bupropion Hydrochloride; BW 323U Hydrochloride; Zyban (trade name); Wellbutrin (trade name); 2-(tert-Butylamino)-1-(3-chlorophenyl)propan-1-one hydrochloride; 1-(3-Chlorophenyl)-2-[(1,1-dimethylethyl)amino]-1-propanone hydrochloride
EINECS	Contact for details

Quality Control

Our Bupropion Hydrochloride is manufactured under strict quality management systems. The product undergoes comprehensive analytical testing to ensure it meets stringent specifications for pharmaceutical intermediates, including identity, purity, and impurity profiles. We provide full traceability and support with regulatory documentation. Certificates of Analysis (COA) are available for every batch upon request, confirming compliance with agreed specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Individual impurity: ≤ 0.5% Total impurities: ≤ 1.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.