Description

Zidovudine CAS NO 30516-87-1 is a nucleoside reverse transcriptase inhibitor (NRTI) and a key active pharmaceutical ingredient (API). It is a critical component in the global fight against HIV/AIDS, serving as a cornerstone in antiretroviral therapy (ART) regimens. This high-purity compound is essential for pharmaceutical manufacturers producing generic and branded antiviral medications, as well as for research institutions engaged in virology and drug development.

Application

• Antiretroviral Drug Manufacturing: Primary API for the production of Zidovudine tablets, capsules, and oral solutions.
• Combination Therapy Formulations: Used in fixed-dose combination (FDC) drugs with other antiretrovirals like Lamivudine.
• Prevention of Maternal-Fetal Transmission: A critical agent in protocols to prevent perinatal transmission of HIV.
• Post-Exposure Prophylaxis (PEP): Component of drug regimens used after potential exposure to HIV.
• Pharmaceutical Research & Development: Reference standard and building block for novel antiviral compound synthesis.
• Contract Manufacturing: Supplied to CDMOs for the production of finished dosage forms for global health programs.

Basic Information

Product Name	Zidovudine
CAS No.	30516-87-1
Molecular Formula	C10H13N5O4
Molecular Weight	267.24 g/mol
Synonyms	AZT; Azidothymidine; Retrovir (Trade Name); 3'-Azido-3'-deoxythymidine; ZDV; BW A509U; Compound S; 1-[(2R,4S,5S)-4-Azido-5-(hydroxymethyl)oxolan-2-yl]-5-methylpyrimidine-2,4-dione
EINECS	250-202-6

Quality Control

Our Zidovudine API is manufactured under strict quality management systems. It is typically produced to meet or exceed USP, Ph. Eur., and ICH Q7 guidelines for active pharmaceutical ingredients. Every batch is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We ensure full traceability and compliance with relevant regulatory requirements for global markets.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); the container must be kept tightly sealed in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference standard
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water (KF)	≤ 1.0%
Related Substances (HPLC)	Individual impurity: ≤ 0.5% Total impurities: ≤ 2.0%
Residual Solvents (GC)	Complies with ICH Q3C
Heavy Metals	≤ 20 ppm
Sulfated Ash	≤ 0.2%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.