Description

Ornithine, L-, [5-14C] CAS NO 30134-60-2 is a carbon-14 labeled derivative of the amino acid L-Ornithine, specifically radiolabeled at the 5-position. This compound is an essential tool for metabolic pathway tracing and pharmacokinetic studies, offering researchers a precise method to track the fate of ornithine in biological systems. It is primarily required by pharmaceutical R&D laboratories, academic research institutions, and CROs (Contract Research Organizations) engaged in advanced studies of the urea cycle, polyamine biosynthesis, and amino acid metabolism.

Application

• Metabolic Pathway Tracing: Used as a radiolabeled tracer to study the urea cycle, arginine biosynthesis, and polyamine (putrescine, spermidine, spermine) production in vivo and in vitro.
• Drug Metabolism and Pharmacokinetics (DMPK): Essential for ADME (Absorption, Distribution, Metabolism, Excretion) studies of new therapeutic compounds targeting ornithine-related pathways.
• Biochemical Research: Serves as a substrate for enzymes like ornithine decarboxylase (ODC) in enzymatic assays to investigate enzyme kinetics and inhibition.
• Nutritional Science Studies: Employed in research on amino acid metabolism, nitrogen balance, and the biochemical effects of dietary supplements.
• Diagnostic Probe Development: Acts as a precursor for synthesizing more complex radiolabeled probes or imaging agents for research purposes.

Basic Information

Product Name	Ornithine, L-, [5-14C]
CAS No.	30134-60-2
Molecular Formula	C5H12N2O2 (with 14C at position 5)
Molecular Weight	~132.16 g/mol (exact mass depends on specific activity)
Synonyms	(2S)-2,5-Diaminopentanoic-5-14C acid; L-Ornithine-5-14C; L-2,5-Diaminovaleric-5-14C acid; (S)-2,5-Diaminopentanoic-5-14C acid; Ornithine (L-)-[5-14C]; [5-14C]-L-Ornithine; L-Ornithine (5-14C); 14C-L-Ornithine
EINECS	Contact for details

Quality Control

Every batch of Ornithine, L-, [5-14C] is manufactured and analyzed under strict quality systems. The product undergoes rigorous testing to ensure compliance with research-grade standards, with key parameters including radiochemical purity (by HPLC), specific activity, and chemical purity. Comprehensive Certificates of Analysis (COA) detailing the analytical results, including chromatographic data and radionuclidic identity, are provided with each shipment to guarantee traceability and reliability for your critical research.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is light-sensitive and should be handled to minimize exposure. For long-term storage, keep the container in a designated freezer dedicated to radiochemicals. Users must follow all applicable laboratory safety and radiation protection guidelines.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Radiochemical Purity (HPLC)	≥ 97%
Specific Activity	50-60 mCi/mmol (Contact for exact value)
Chemical Purity (HPLC)	≥ 95%
Solvent (if supplied in solution)	Specified on COA

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.