Description

8-Hydroxyguanosine is a significant oxidized nucleoside derivative and a key biomarker for oxidative stress and RNA damage. Its precise quantification is critical for research into aging, neurodegenerative diseases, and cancer mechanisms, where oxidative damage plays a central role. This high-purity biochemical is essential for researchers and manufacturers in the life sciences, pharmaceutical R&D, and diagnostic kit production sectors.

Application

• Biomarker Research: Primary standard for the quantification of oxidative stress in cellular and animal models.
• Diagnostic Development: Critical reference compound in the development of ELISA kits and LC-MS/MS assays for disease monitoring.
• Pharmaceutical R&D: Used in studies investigating the efficacy of antioxidants and therapeutic agents targeting oxidative damage pathways.
• Metabolomics & Clinical Chemistry: An important analyte in metabolic profiling and studies of age-related diseases.
• Academic Research: Fundamental tool in biochemistry and molecular biology laboratories for studying DNA/RNA oxidation.
• Quality Control: Serves as a reference standard for analytical method validation in contract research organizations (CROs) and quality control labs.

Basic Information

Product Name	8-Hydroxyguanosine
CAS No.	3868-31-3
Molecular Formula	C10H13N5O6
Molecular Weight	299.24 g/mol
Synonyms	8-OH-Guo; 8-Oxo-7,8-dihydroguanosine; 8-Oxoguanosine; Guanosine, 8-hydroxy-; 8-Hydroxy-2'-deoxyguanosine analog; RNA oxidation marker; Oxidative stress biomarker; 8-oxo-Guo
EINECS	223-389-8

Quality Control

Our 8-Hydroxyguanosine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopy, to ensure it meets the high standards required for research and diagnostic applications. A detailed Certificate of Analysis (COA) with batch-specific data is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and light-sensitive; prolonged exposure to ambient conditions should be avoided to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Heavy Metals	≤ 20 ppm
Residual Solvents	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.