Description

[(2R,5R)-5-(6-Aminopurin-9-Yl)-3-Hydroxy-4-Phosphonooxy-Oxolan-2-Yl]Me Thoxyphosphonic Acid CAS NO 3805-37-6 is a chemically modified nucleotide analog of significant interest in advanced pharmaceutical research and development. This compound serves as a critical building block and biochemical tool for investigating and modulating enzymatic pathways, particularly those involving nucleotide metabolism. It is primarily utilized by research institutions, pharmaceutical companies, and biotechnology firms engaged in the synthesis of novel therapeutic agents, including antivirals and anticancer drugs.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel nucleoside-based antiviral and anticancer agents.
• Biochemical Research: Tool compound for studying enzyme kinetics, inhibition, and the mechanisms of nucleotide-metabolizing enzymes like polymerases and kinases.
• Proteomics & Molecular Biology: Used in the development of probes and labeled analogs for tracking biological processes.
• Medicinal Chemistry: Serves as a scaffold for structure-activity relationship (SAR) studies to optimize drug potency and selectivity.
• Diagnostic Reagent Development: Potential component in the formulation of diagnostic kits targeting specific enzymatic activities.

Basic Information

Product Name	[(2R,5R)-5-(6-Aminopurin-9-Yl)-3-Hydroxy-4-Phosphonooxy-Oxolan-2-Yl]Me Thoxyphosphonic Acid
CAS No.	3805-37-6
Molecular Formula	C11H17N5O10P2
Molecular Weight	441.23 g/mol
Synonyms	9-[(2R,3R,4S,5R)-3,4-Dihydroxy-5-[(phosphonomethoxy)methyl]oxolan-2-yl]purin-6-amine; PMEA intermediate; Adefovir precursor; (R)-PMPA derivative; 9-[2-(Phosphonomethoxy)propyl]adenine analog; Nucleotide phosphonate; GS-7340 related compound; Antiviral nucleotide analog
EINECS	Contact for details

Quality Control

Our [(2R,5R)-5-(6-Aminopurin-9-Yl)-3-Hydroxy-4-Phosphonooxy-Oxolan-2-Yl]Me Thoxyphosphonic Acid is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are available upon request, supporting compliance with research and cGMP-grade material requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.