Description

12β-Hydroxybufalin is a specific, high-purity bufadienolide compound, a derivative of bufalin, identified by CAS NO 3714-45-2. This compound is of significant interest in advanced pharmaceutical research and development due to its potent biological activity profile. It is primarily utilized by researchers and manufacturers in the life sciences sector for investigating novel therapeutic pathways and developing high-value active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical R&D Intermediate: A key building block in the synthesis and study of novel cardioactive or anticancer therapeutic agents.
• Reference Standard: Used as a certified reference material (CRM) in analytical laboratories for quality control and method validation of related products.
• Biochemical Research: Employed in pharmacological studies to investigate mechanisms of action related to Na+/K+-ATPase inhibition and cell signaling pathways.
• Precursor for Derivatives: Serves as a starting material for the semi-synthesis of other specialized bufadienolide analogs with modified activity.

Basic Information

Product Name	12β-Hydroxybufalin
CAS No.	3714-45-2
Molecular Formula	C₂₄H₃₄O₅
Molecular Weight	402.52 g/mol
Synonyms	12β-Hydroxybufalin; 3β,12β,14-Trihydroxybufa-20,22-dienolide; 14β,15β-Epoxy-3β,12β-dihydroxy-5β-bufa-20,22-dienolide; Bufalin, 12-hydroxy-; 12-Hydroxybufalin
EINECS	Contact for details

Quality Control

Our 12β-Hydroxybufalin is produced and tested under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the high standards required for research and development applications. A detailed Certificate of Analysis (COA) is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.