Description

Glucose, D-, [3,4-14C] CAS NO 3714-18-9 is a radiolabeled form of D-glucose, a fundamental carbohydrate, where the carbon atoms at positions 3 and 4 are replaced with the radioactive isotope carbon-14. This specific labeling is critical for tracing metabolic pathways, enabling precise quantification and visualization of glucose uptake and utilization in biological systems. It is an indispensable tool for researchers and scientists in pharmaceutical development, metabolic studies, and biochemical research requiring high-specific-activity tracers.

Application

• Metabolic Pathway Tracing: Used in in vitro and in vivo studies to elucidate glycolysis, gluconeogenesis, and the pentose phosphate pathway.
• Drug Discovery & Development: Employed in ADME (Absorption, Distribution, Metabolism, and Excretion) studies to investigate the effects of new drug candidates on cellular glucose metabolism.
• Oncology Research: Applied in studies of the Warburg effect to measure glucose uptake rates in cancer cells and tumors.
• Biochemical Assay Development: Serves as a labeled substrate in enzymatic assays for hexokinase, glucose-6-phosphate dehydrogenase, and other metabolic enzymes.
• Neuroscience Research: Utilized in brain slice and neuronal culture studies to monitor energy metabolism and synaptic activity.
• Microbial Metabolism Studies: Tracks carbon assimilation and metabolic flux in bacteria, yeast, and other microorganisms.
• Agricultural & Plant Biochemistry: Investigates photosynthesis, carbon fixation, and sugar transport mechanisms in plants.

Basic Information

Product Name	Glucose, D-, [3,4-14C]
CAS No.	3714-18-9
Molecular Formula	C6H12O6 (with 14C at positions 3 & 4)
Molecular Weight	~180.16 g/mol (exact mass depends on specific activity)
Synonyms	D-[3,4-14C]Glucose; [3,4-14C]-D-Glucose; D-Glucose-3,4-14C; Radiolabeled D-Glucose; 14C-Glucose; Dextrose-3,4-14C; (3,4-14C)Glucose; D-Glucose (3,4-14C)
EINECS	Contact for details

Quality Control

Every batch of Glucose, D-, [3,4-14C] is manufactured and analyzed under strict quality systems. We guarantee high radiochemical purity (>97%) and specific activity as specified. Identity is confirmed by co-chromatography with an authentic standard. Certificates of Analysis (COA) detailing radiochemical purity, specific activity, chemical purity, and solvent composition are provided with each shipment to ensure traceability and compliance with your research protocols.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C or as specified on the label. This product is hygroscopic (moisture-sensitive). For long-term storage, keep the vial in its original packaging in a dedicated freezer. Users must follow all applicable radiation safety guidelines for handling and disposal.

Specification

Item	Specification
Appearance	White to off-white solid or solution (as specified)
Identification (HPLC/Co-chromatography)	Conforms to standard
Radiochemical Purity (HPLC)	≥ 97%
Specific Activity	50-60 mCi/mmol (Contact for specific value)
Chemical Purity (HPLC-UV/RI)	≥ 95%
Solvent (if supplied as solution)	Ethanol:Water (9:1) or as specified
Concentration (if supplied as solution)	1.0 mCi/mL ± 10% (Contact for details)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.