Description

Glucose, D-, [2-14C] CAS NO 3646-71-7 is a radiolabeled isotopologue of D-glucose, a fundamental carbohydrate, where the carbon atom at the 2-position is replaced with the radioactive isotope carbon-14. This specific labeling is crucial for tracing the metabolic fate of glucose in biochemical and pharmacological research. It is an essential tool for scientists in pharmaceutical development, metabolic disease research, and biochemistry who require precise tracking of glucose utilization and conversion pathways.

Application

• Metabolic Pathway Tracing: Used as a radioactive tracer to study glycolysis, gluconeogenesis, and the pentose phosphate pathway in cell cultures, tissues, and whole organisms.
• Drug Metabolism & Pharmacokinetics (DMPK): Employed in ADME (Absorption, Distribution, Metabolism, Excretion) studies to investigate how new drug candidates affect glucose metabolism and energy homeostasis.
• Biomedical Research: Applied in research on diabetes, cancer metabolism (Warburg effect), and other metabolic disorders to quantify glucose uptake and flux.
• Enzymology Studies: Serves as a substrate for kinetic studies of enzymes like hexokinase, glucokinase, and glucose-6-phosphate dehydrogenase.
• Microbial Metabolism: Used to study carbon assimilation and metabolic engineering in bacteria, yeast, and other microorganisms.
• Radiochemical Synthesis: Acts as a labeled precursor for the synthesis of other carbon-14 labeled compounds, such as glycosides or metabolic intermediates.

Basic Information

Product Name	Glucose, D-, [2-14C]
CAS No.	3646-71-7
Molecular Formula	C6H12O6 (with 14C at C-2)
Molecular Weight	~180.16 g/mol (exact mass depends on specific activity)
Synonyms	D-[2-14C]Glucose; [2-14C]-D-Glucose; 2-14C-D-Glucose; D-Glucose-2-14C; (2-14C)Glucose; Radiolabeled D-Glucose; Carbon-14 Labeled Glucose; Dextrose-2-14C
EINECS	Contact for details

Quality Control

Every batch of Glucose, D-, [2-14C] is manufactured and analyzed under strict quality control protocols to ensure high radiochemical purity and specific activity. Identity and purity are confirmed via techniques including HPLC with radiometric detection. Certificates of Analysis (COA) are provided, detailing radiochemical purity, specific activity, chemical purity, and solvent composition.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C or as specified on the label. This product is hygroscopic (moisture-sensitive). For long-term storage, consider conditions recommended for radioactive materials. Keep away from incompatible substances.

Specification

Item	Specification
Appearance	White to off-white solid or solution (as specified)
Identification (HPLC, TLC)	Conforms to standard
Radiochemical Purity (HPLC)	≥ 97%
Specific Activity	50-60 mCi/mmol (Contact for exact value)
Chemical Purity (HPLC-UV/RI)	≥ 98%
Solvent (if supplied as solution)	Ethanol:Water mixture or as specified

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.