Description

L-Arginine-[2,3-3H] is a high-specific-activity, tritium-labeled derivative of the essential amino acid L-arginine. This labeled compound is a critical tool for researchers requiring precise metabolic and pharmacokinetic tracing in biological systems. It is primarily utilized in life science research, pharmaceutical development, and biochemical studies where tracking the fate of arginine is essential. The product is supplied with guaranteed radiochemical purity and specific activity to ensure reliable and reproducible experimental results.

Application

• Metabolic Pathway Tracing: Used to study the urea cycle, nitric oxide synthesis, and polyamine biosynthesis in cell cultures and animal models.
• Pharmacokinetic & ADME Studies: Essential for investigating the absorption, distribution, metabolism, and excretion (ADME) of arginine-based drug candidates.
• Protein & Peptide Research: Employed in radiolabeling studies to investigate protein turnover, degradation rates, and incorporation into newly synthesized peptides.
• Receptor Binding Assays: Serves as a radioligand in studies targeting arginine-sensitive receptors and transporters.
• Biochemical Mechanism Elucidation: Aids in unraveling enzymatic mechanisms involving arginine as a substrate or modulator.
• Diagnostic Research: Potential use in the development of novel diagnostic probes and imaging agents.

Basic Information

Product Name	L-Arginine-[2,3-3H]
CAS No.	3641-46-1
Molecular Formula	C₆H₁₄N₄O₂ (³H-labeled)
Molecular Weight	~177.2 g/mol (unlabeled base)
Synonyms	(2S)-2-Amino-5-(³H)guanidinopentanoic acid; (S)-2-Amino-5-[amino(³H)iminomethyl]aminopentanoic acid; L-(³H)Arginine; [2,3-³H]-L-Arginine; Arg-³H; Tritiated L-Arginine; H-Arg-³H; Labeled L-Arginine
EINECS	Contact for details

Quality Control

Every batch of L-Arginine-[2,3-3H] is manufactured and analyzed under strict quality control protocols to ensure the highest standards of radiochemical purity and specific activity. Our products undergo rigorous testing, including HPLC and radio-HPLC analysis, to confirm identity, purity, and radiochemical concentration. A comprehensive Certificate of Analysis (COA) detailing specific activity (Ci/mmol or GBq/mmol), radiochemical purity, chemical purity, and solvent composition is provided with each shipment to guarantee consistency for your critical research.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). For long-term storage, keep the vial sealed in its original packaging in a dedicated freezer. Allow the vial to equilibrate to room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	Colorless to pale yellow solution
Identification (HPLC/Co-Elution)	Conforms to reference standard
Specific Activity	20-80 Ci/mmol (740-2960 GBq/mmol)
Radiochemical Purity (HPLC)	≥ 95%
Chemical Purity (HPLC)	≥ 98%
Concentration	1 mCi/mL (37 MBq/mL) in ethanol:water (7:3)
Solvent System	Ethanol:Water (7:3 v/v)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.