Description

Rivastigmine12 CAS NO 3441-03-2 is a high-purity pharmaceutical intermediate and active ingredient of significant commercial and therapeutic importance. Its primary value lies in its role as a key building block for the synthesis of Rivastigmine, a potent and selective acetylcholinesterase inhibitor used in the treatment of dementia associated with Alzheimer's and Parkinson's diseases. This compound is essential for research institutions, pharmaceutical development laboratories, and large-scale API manufacturers requiring a reliable and consistent supply of critical raw materials. Our product is supplied under stringent quality control to meet the exacting standards of the global pharmaceutical supply chain.

Application

• Active Pharmaceutical Ingredient (API) Synthesis: Primary use as a critical intermediate in the commercial production of Rivastigmine and its pharmaceutical salts (e.g., Rivastigmine tartrate).
• Pharmaceutical Research & Development: Serves as a key starting material (KSM) or advanced intermediate in the development of new cognitive-enhancing therapeutics and novel drug delivery systems.
• Reference Standard: Used in analytical laboratories as a high-purity chemical reference standard for method development, validation, and quality control testing of finished drug products.
• Process Chemistry & Scale-Up: Employed in process optimization studies and the scale-up of manufacturing routes for cholinesterase inhibitor类药物.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) engaged in the production of generic or innovator neurological medications.

Basic Information

Product Name	Rivastigmine12
CAS No.	3441-03-2
Molecular Formula	C14H22N2O2
Molecular Weight	250.34 g/mol
Synonyms	(S)-3-[1-(Dimethylamino)ethyl]phenyl ethyl(methyl)carbamate; (S)-N-Ethyl-N-methyl-3-[1-(dimethylamino)ethyl]phenyl carbamate; SDZ ENA 713; Exelon Intermediate; Rivastigmine Base; Rivastigmine Free Base; ENA 713; ZNS 123
EINECS	Contact for details

Quality Control

Every batch of Rivastigmine12 is manufactured and tested under a strict quality management system. We ensure compliance with relevant ICH guidelines and can supply material that meets in-house specifications aligned with pharmaceutical intermediate requirements. Comprehensive testing includes identity, purity, and impurity profile analysis. A Certificate of Analysis (COA) detailing all test results is provided with each shipment to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen) at a controlled room temperature (15-25°C) in a dry, well-ventilated area. Due to its sensitivity to light and oxidation, prolonged exposure to air and light should be avoided.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.5%
Related Substances (HPLC)	Total impurities ≤ 1.0% Any single impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Heavy Metals	≤ 20 ppm
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.