Description

Arachidonic Acid, [1-14C]- is a carbon-14 radiolabeled analog of the essential polyunsaturated ω-6 fatty acid. This compound is a critical tool for metabolic pathway tracing and pharmacokinetic studies, offering researchers precise tracking capabilities. It is primarily utilized by scientists in the pharmaceutical, biotechnology, and life sciences sectors for advanced research applications.

Application

• Biochemical Research: As a tracer for studying the metabolism, biosynthesis, and catabolism of arachidonic acid and its derivatives (eicosanoids) in biological systems.
• Drug Discovery & Development: For investigating the mechanism of action of anti-inflammatory drugs, COX/LOX inhibitors, and other pharmaceuticals that target the arachidonic acid cascade.
• Metabolic Pathway Analysis: Enabling detailed mapping of lipid metabolic pathways, including β-oxidation and incorporation into complex lipids like phospholipids.
• In Vitro & In Vivo Studies: Used in cell culture and animal models to track the distribution, absorption, and excretion of arachidonic acid.
• Analytical Method Development: Serving as an internal standard or reference material in LC-MS, GC-MS, and other chromatographic assays for quantitative analysis.
• Nutritional Science Research: Investigating the role of dietary arachidonic acid in inflammation, immune response, and cellular signaling.

Basic Information

Product Name	Arachidonic Acid, [1-14C]-
CAS No.	3435-81-2
Molecular Formula	C₂₀H₃₂O₂ (¹⁴C labeled at position 1)
Molecular Weight	~304.5 g/mol (exact mass depends on specific activity)
Synonyms	(5Z,8Z,11Z,14Z)-5,8,11,14-Eicosatetraenoic-1-¹⁴C Acid; AA-1-¹⁴C; ARA-1-¹⁴C; all-cis-5,8,11,14-Eicosatetraenoic-1-¹⁴C Acid; Immunocytophilin Ligand-1-¹⁴C; ¹⁴C-Arachidonic Acid
EINECS	222-355-0 (for unlabeled Arachidonic Acid)

Quality Control

Every batch of Arachidonic Acid, [1-14C]- is manufactured and analyzed under strict quality systems. The product undergoes rigorous testing to ensure high chemical and radiochemical purity, precise specific activity, and conformity to customer specifications. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing identity, purity, specific activity, radiochemical concentration, and solvent composition.

Storage

Preserve in a tightly closed container, protected from light. Store at or below -20°C. For long-term storage, keep under an inert atmosphere (argon or nitrogen) to prevent oxidation. This product is a radioactive material and must be stored and handled in accordance with all applicable local and national radiation safety regulations.

Specification

Item	Specification
Appearance	Clear, colorless to pale yellow solution
Identification (HPLC/Radio-HPLC)	Conforms to reference standard
Chemical Purity (HPLC)	≥ 98%
Radiochemical Purity (Radio-HPLC)	≥ 97%
Specific Activity	50-60 mCi/mmol (Contact for exact value)
Concentration	0.1 mCi/mL in ethanol (or as specified)
Solvent	Ethanol (with optional stabilizer)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.