Description

2',3'-Dideoxythymidine CAS NO 3416-05-5 is a synthetic nucleoside analog, a key intermediate in the synthesis of modified nucleic acids and antiviral compounds. Its primary value lies in its role as a foundational building block for research into nucleoside-based therapeutics and molecular biology probes. This high-purity chemical is essential for pharmaceutical R&D laboratories, biotechnology companies, and academic institutions focused on virology, oncology, and genetic research.

Application

• Antiviral Drug Intermediate: Critical precursor in the synthesis of nucleoside reverse transcriptase inhibitors (NRTIs) and other antiviral agents.
• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies, particularly those involving DNA polymerases and reverse transcriptases.
• Molecular Probe Development: Serves as a building block for creating labeled or modified nucleotides used in diagnostics and genomic sequencing.
• Organic Synthesis: A versatile intermediate for medicinal chemists creating novel nucleoside analogs with potential therapeutic activity.
• Academic & Pharmaceutical R&D: Fundamental material for investigating mechanisms of DNA chain termination and for developing new therapeutic candidates.

Basic Information

Product Name	2',3'-Dideoxythymidine
CAS No.	3416-05-5
Molecular Formula	C10H14N2O4
Molecular Weight	226.23 g/mol
Synonyms	2',3'-Dideoxythymidine; 2',3'-ddT; Dideoxythymidine; ddThd; 1-[(2R,5S)-5-(Hydroxymethyl)oxolan-2-yl]-5-methylpyrimidine-2,4-dione; Thymidine, 2',3'-dideoxy-; NSC 404095
EINECS	222-314-7

Quality Control

Our 2',3'-Dideoxythymidine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing including HPLC for purity, NMR and IR for structural confirmation, and stringent controls for residual solvents and impurities. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to ensure traceability and compliance with your research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Complies with ICH guidelines
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.