Description

L-Tyr-Nca CAS NO 3415-08-5 is a high-purity N-carboxyanhydride (NCA) derivative of the amino acid L-tyrosine, serving as a critical building block for the controlled synthesis of polypeptides and advanced polymeric materials. This compound matters because it enables the precise, ring-opening polymerization required to create well-defined peptide-based structures with specific functionalities. It is essential for researchers and manufacturers in pharmaceutical development, biomaterials engineering, and specialty polymer chemistry who require reliable, high-quality monomers.

Application

• Synthesis of Tyrosine-Containing Peptides and Polypeptides: Used as a key monomer in ring-opening polymerization (ROP) to incorporate L-tyrosine residues into custom peptide sequences.
• Biomedical Material Fabrication: Enables the production of biodegradable and biocompatible polymers for drug delivery systems, tissue engineering scaffolds, and surgical implants.
• Advanced Polymer Research: Serves as a precursor for creating stimuli-responsive or functionalized polymers with properties like pH-sensitivity or specific bioactivity.
• Pharmaceutical Intermediate: Acts as a building block in the research and development of novel therapeutic peptides and protein-mimetics.
• Surface Modification Agent: Used to graft peptide functionalities onto surfaces for biosensor development or to create bioactive coatings.
• Academic and Industrial R&D: A fundamental reagent for studying polymerization kinetics and developing new synthetic methodologies in peptide chemistry.

Basic Information

Product Name	L-Tyr-Nca
CAS No.	3415-08-5
Molecular Formula	C12H11NO5
Molecular Weight	249.22 g/mol
Synonyms	L-Tyrosine N-Carboxyanhydride; NCA-L-Tyrosine; (S)-2,5-Dioxo-4-(4-hydroxyphenyl)oxazolidine; L-Tyrosine NCA; O4-Benzyl-N-carboxy-L-tyrosine anhydride (common misnomer); Tyrosine NCA; N-Carboxy-L-tyrosine anhydride; 4-(4-Hydroxyphenyl)-2,5-oxazolidinedione
EINECS	Contact for details

Quality Control

Our L-Tyr-Nca is produced and tested under stringent quality management protocols to ensure batch-to-batch consistency and high purity, suitable for sensitive research and production applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant GMP principles for pharmaceutical-grade intermediates, ensuring traceability and documentation for regulated markets.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when opened for use to prevent hydrolysis and maintain reactivity. Long-term storage at lower temperatures (e.g., 2-8°C) under desiccant is recommended.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Solubility	Soluble in anhydrous DMF, DMSO, THF

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.