Description

Adenosine, [8-14C] CAS NO 3257-92-9 is a radiolabeled derivative of adenosine, a fundamental nucleoside in biochemistry. This compound is specifically labeled with carbon-14 at the 8-position of the purine ring, making it an indispensable tool for metabolic pathway tracing and pharmacokinetic studies. It is essential for researchers and quality control laboratories in the pharmaceutical, biotechnology, and life science sectors who require precise tracking of adenosine uptake, incorporation, and catabolism.

Application

• Biochemical Research: Used as a tracer to study adenosine metabolism, nucleotide synthesis, and energy transfer mechanisms (ATP/ADP/AMP cycles).
• Drug Metabolism and Pharmacokinetics (DMPK): Critical for radiolabeled ADME (Absorption, Distribution, Metabolism, Excretion) studies of adenosine receptor agonists, antagonists, and related cardiovascular or anti-inflammatory drug candidates.
• Enzymology Studies: Serves as a substrate for enzymes such as adenosine deaminase, adenosine kinase, and S-adenosylhomocysteine hydrolase to investigate enzyme kinetics and inhibition.
• Diagnostic Agent Development: Employed in the research and development of novel diagnostic imaging agents and radiopharmaceuticals.
• Cell Signaling Research: Utilized to trace the role of adenosine and its receptors in cellular signaling pathways, including those related to sleep regulation, vasodilation, and immune response.
• Quality Control & Reference Standard: Acts as an analytical reference standard in HPLC or LC-MS methods for quantifying adenosine or its metabolites in various samples.

Basic Information

Product Name	Adenosine, [8-14C]
CAS No.	3257-92-9
Molecular Formula	C10H1314CN5O4
Molecular Weight	Contact for details (varies with specific activity)
Synonyms	8-14C-Adenosine; Adenosine-8-14C; [8-14C]Adenosine; 9-β-D-Ribofuranosyladenine-8-14C; 6-Amino-9-β-D-ribofuranosyl-9H-purine-8-14C; (8-14C)Adenosine; Adenosine (8-14C); Radiolabeled Adenosine
EINECS	Contact for details

Quality Control

Every batch of Adenosine, [8-14C] is manufactured and analyzed under strict quality systems. Radiochemical purity and chemical purity are determined by validated analytical methods such as HPLC with radiometric detection. Certificates of Analysis (COA) are provided, detailing specific activity, purity, solvent composition, and analytical chromatograms to ensure traceability and compliance with research standards.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store frozen at -20°C or below. The product is light-sensitive (store away from light). Allow the vial to reach room temperature before opening to minimize moisture condensation. Store in accordance with local regulations for radioactive materials.

Specification

Item	Specification
Appearance	White to off-white solid or solution (specify solvent)
Identification (HPLC)	Co-elutes with reference standard
Specific Activity	Contact for details (mCi/mmol)
Radiochemical Purity (HPLC)	≥ 97%
Chemical Purity (HPLC)	≥ 95%
Solvent (if supplied as solution)	Ethanol:Water or specified
Concentration	Contact for details (µCi/mL or mCi/mL)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.