Description

Stavudine CAS NO 3056-17-5 is a synthetic thymidine nucleoside analog that acts as a potent antiretroviral agent. It is a critical active pharmaceutical ingredient (API) used in the formulation of combination therapies for managing HIV-1 infection. This high-purity compound is essential for pharmaceutical manufacturers and research institutions developing antiviral medications. Its role in inhibiting viral reverse transcriptase makes it a key component in global public health initiatives.

Application

• Antiretroviral Drug Formulation: Primary use as the active pharmaceutical ingredient (API) in the manufacture of stavudine capsules, tablets, and oral solutions for HIV/AIDS treatment.
• Fixed-Dose Combination Therapies: Used in combination with other antiretroviral agents like lamivudine and nevirapine for enhanced therapeutic efficacy.
• Pharmaceutical Research & Development: Serves as a reference standard and key intermediate in the R&D of new nucleoside reverse transcriptase inhibitors (NRTIs) and related antiviral compounds.
• Clinical Trial Material: Supplied as a high-purity bulk active substance for use in clinical studies and bioequivalence testing.
• Generic Drug Manufacturing: A vital raw material for producers of generic antiretroviral medications, supporting affordable global access to treatment.

Basic Information

Product Name	Stavudine
CAS No.	3056-17-5
Molecular Formula	C10H12N2O4
Molecular Weight	224.21 g/mol
Synonyms	2',3'-Didehydro-2',3'-dideoxythymidine; d4T; Zerit® (Brand Name); Stavudin; Stavudina; Stavudinum; BMY-27857; 1-((2R,5S)-5-(Hydroxymethyl)-2,5-dihydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione
EINECS	221-278-9

Quality Control

Our Stavudine is manufactured under strict quality management systems, targeting specifications that meet or exceed major pharmacopoeial standards such as USP and EP. Every batch undergoes comprehensive analytical testing, including identity confirmation, purity assay, and impurity profiling. A Certificate of Analysis (COA) detailing all test results is provided with each shipment to ensure full traceability and compliance for our pharmaceutical partners.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	NMT 1.0%
Residue on Ignition	NMT 0.1%
Related Substances (HPLC)	Total impurities: NMT 1.0% Any individual impurity: NMT 0.5%
Heavy Metals	NMT 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.