Description

(4-Fluoro-Benzenesulfonyl)-Acetic Acid is a versatile organosulfur building block characterized by its benzenesulfonyl and acetic acid functional groups, with a fluorine substituent enhancing its reactivity and electronic properties. This compound is crucial for the synthesis of complex molecules, particularly in pharmaceutical research and fine chemical manufacturing, where it serves as a key intermediate. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing sulfonamide derivatives and other active compounds.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for drugs targeting metabolic and inflammatory pathways.
• Agrochemical Synthesis: Used in the development of novel herbicides and fungicides, leveraging the sulfonyl group for biological activity.
• Material Science Research: Employed in the creation of specialty polymers and advanced materials where sulfone linkages are required.
• Chemical Biology & Proteomics: Acts as a reactive handle in bioconjugation chemistry and the development of enzyme inhibitors.
• Organic Synthesis Building Block: Utilized in palladium-catalyzed cross-coupling reactions and nucleophilic substitution reactions to introduce the fluoro-benzenesulfonyl moiety.
• Ligand and Catalyst Development: Serves as a starting material for synthesizing novel ligands used in asymmetric catalysis.

Basic Information

Product Name	(4-Fluoro-Benzenesulfonyl)-Acetic Acid
CAS No.	383-38-0
Molecular Formula	C8H7FO4S
Molecular Weight	218.20 g/mol
Synonyms	4-Fluorobenzenesulfonylacetic Acid; (p-Fluorophenylsulfonyl)acetic Acid; 2-[(4-Fluorophenyl)sulfonyl]acetic Acid; 4-Fluoro-benzenesulfonyl-acetic acid; NSC 403697; p-Fluorobenzenesulfonylacetic Acid; 4-Fluorobenzene-1-sulfonylacetic Acid; (4-Fluorophenylsulfonyl)acetic Acid
EINECS	206-848-8

Quality Control

Our (4-Fluoro-Benzenesulfonyl)-Acetic Acid is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and FTIR, to ensure high purity and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical parameters. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring traceability and reliability for your critical R&D and production processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after each use to prevent degradation from atmospheric moisture. Keep away from incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Heavy Metals	≤ 20 ppm
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.