Description

4-Fluoro-2-Nitro-α-Oxo-Benzene Propanoic Acid Ethyl Ester is a specialized fluorinated and nitrated aromatic ester, serving as a critical building block in advanced organic synthesis. Its unique molecular architecture, featuring both electron-withdrawing and reactive functional groups, makes it a versatile intermediate for constructing complex pharmacophores and agrochemicals. This high-purity compound is essential for research and development chemists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to introduce specific fluorinated motifs into target molecules.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly those requiring fluorinated aromatic systems for enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides, where the fluorine atom can improve lipophilicity and biological activity.
• Material Science Research: Serves as a monomer or functionalizing agent in the creation of advanced polymers and liquid crystals with specific optical or electronic properties.
• Chemical Biology Probes: Employed in the design and synthesis of fluorinated probes and tags for studying biological processes and enzyme mechanisms.
• Organic Synthesis Building Block: A versatile reagent for palladium-catalyzed cross-coupling reactions, nucleophilic aromatic substitution, and other transformations to create diverse chemical libraries.

Basic Information

Item	Details
Product Name	4-Fluoro-2-Nitro-α-Oxo-Benzene Propanoic Acid Ethyl Ester
CAS No.	346-43-0
Molecular Formula	C₁₁H₁₀FNO₅
Molecular Weight	255.20 g/mol
Synonyms	Ethyl 4-Fluoro-2-nitrobenzoylacetate; 4-Fluoro-2-nitrobenzoylacetic Acid Ethyl Ester; 2-Nitro-4-fluorobenzoylacetic Acid Ethyl Ester; Ethyl (4-Fluoro-2-nitrobenzoyl)acetate; Ethyl 2-(4-Fluoro-2-nitrobenzoyl)acetate; Acetic acid, 2-(4-fluoro-2-nitrobenzoyl)-, ethyl ester; NSC 406106
EINECS	Contact for details

Quality Control

Our production of 4-Fluoro-2-Nitro-α-Oxo-Benzene Propanoic Acid Ethyl Ester adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity. Each lot is analyzed using advanced techniques including HPLC, GC, and NMR spectroscopy to verify identity, potency, and impurity profiles. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment, ensuring full transparency and compliance with your research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed to prevent degradation from atmospheric moisture. Keep away from heat sources and incompatible materials.

Specification

Item	Specification
Appearance	Yellow to light brown crystalline powder or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 1.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.