Description

2-Hydroxy-4-Trifluoromethyl-Benzoic Acid Methyl Ester is a versatile fluorinated aromatic ester that serves as a critical building block in advanced chemical synthesis. Its value lies in the unique combination of the trifluoromethyl group, which imparts enhanced metabolic stability and lipophilicity, and the reactive methyl ester and phenolic hydroxyl functionalities. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries seeking to incorporate fluorine into target molecules to optimize their biological activity and physical properties.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in the synthesis of molecules targeting central nervous system (CNS) disorders, anti-inflammatory agents, and antimicrobials.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances compound efficacy and environmental persistence.
• Liquid Crystal & OLED Materials: Serves as a precursor in the synthesis of fluorinated organic electronic materials, contributing to improved performance and stability in display and lighting technologies.
• Advanced Polymer Modifiers: Incorporated as a monomer or additive to create specialty polymers with tailored surface properties, chemical resistance, and optical characteristics.
• Chemical Research & Development: Employed as a standard or starting material in academic and industrial R&D for exploring new fluorination methodologies and structure-activity relationships (SAR).
• Dye & Pigment Intermediate: Utilized in the synthesis of specialized fluorinated dyes and pigments that offer superior lightfastness and color properties.

Basic Information

Product Name	2-Hydroxy-4-Trifluoromethyl-Benzoic Acid Methyl Ester
CAS No.	345-28-8
Molecular Formula	C9H7F3O3
Molecular Weight	220.15 g/mol
Synonyms	Methyl 2-Hydroxy-4-(trifluoromethyl)benzoate; 4-(Trifluoromethyl)salicylic Acid Methyl Ester; Methyl 4-(Trifluoromethyl)salicylate; 2-Hydroxy-4-trifluoromethylbenzoic Acid Methyl Ester; Benzoic acid, 2-hydroxy-4-(trifluoromethyl)-, methyl ester; Methyl 2-hydroxy-α,α,α-trifluoro-p-toluate
EINECS	Contact for details

Quality Control

Every batch of our 2-Hydroxy-4-Trifluoromethyl-Benzoic Acid Methyl Ester is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the precise requirements for advanced synthetic applications. A detailed Certificate of Analysis (COA) is supplied with each shipment, documenting key parameters such as identity, purity, and impurity profiles as determined by HPLC, GC, NMR, and IR spectroscopy.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). This compound is sensitive to fluoride and strong alkali; ensure it is stored separately from such materials to prevent decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.