Description

4-(Trifluoromethylthio)Benzoic Acid is a versatile fluorinated aromatic building block characterized by a benzoic acid core substituted with a trifluoromethylthio group. This unique structure imparts valuable properties such as enhanced lipophilicity and metabolic stability, making it a critical intermediate in advanced synthesis. It is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for creating novel active ingredients.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in the development of drugs targeting central nervous system and metabolic diseases.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the trifluoromethylthio group can improve biological activity and environmental profile.
• Liquid Crystal Materials: Serves as a precursor in the manufacture of fluorinated liquid crystals for high-performance displays.
• Organic Synthesis & Chemical Research: A valuable reagent for introducing the SCF3 moiety into complex molecules, facilitating structure-activity relationship (SAR) studies and novel compound libraries.
• Polymer Modification: Employed to create specialty monomers for engineering plastics and coatings with specific chemical resistance or surface properties.

Basic Information

Product Name	4-(Trifluoromethylthio)Benzoic Acid
CAS No.	330-17-6
Molecular Formula	C8H5F3O2S
Molecular Weight	222.18 g/mol
Synonyms	4-(Trifluoromethylsulfanyl)benzoic acid; p-(Trifluoromethylthio)benzoic acid; Benzoic acid, 4-[(trifluoromethyl)thio]-; α,α,α-Trifluoro-p-thiocresotic acid; 4-(Trifluoromethylmercapto)benzoic acid; 4-SCF3-Benzoic acid; p-Trifluoromethylthiobenzoic acid
EINECS	206-350-7

Quality Control

Our 4-(Trifluoromethylthio)Benzoic Acid is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation by IR and NMR spectroscopy, to ensure it meets the high standards required for research and industrial synthesis. Certificates of Analysis (COA) with detailed specifications are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Melting Point	142 - 146 °C
Loss on Drying	≤0.5%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.