Description

2-Fluoro-5-Methylbenzoic Acid is a versatile fluorinated aromatic building block of significant importance in advanced organic synthesis. Its molecular structure, featuring both a carboxylic acid and a fluorine substituent on a methylbenzene ring, makes it a critical intermediate for creating complex molecules with tailored properties. This compound is essential for research and development chemists and process engineers in the pharmaceutical and agrochemical industries, where it is used to introduce fluorinated motifs that can enhance metabolic stability, bioavailability, and binding affinity in active ingredients.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in the development of fluorinated drug candidates for oncology, CNS disorders, and anti-infectives.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and pesticides, where the fluorine atom improves lipophilicity and biological activity.
• Liquid Crystal & OLED Materials: Serves as a precursor in the manufacture of fluorinated components for electronic display materials and organic light-emitting diodes.
• Polymer Modification: Employed to introduce fluorine-containing side chains into polymers, enhancing their chemical resistance, thermal stability, and surface properties.
• Organic Synthesis Reagent: A valuable reagent in coupling reactions (e.g., Suzuki, Heck) and for preparing derivatives like amides, esters, and acid chlorides for further functionalization.
• Chemical Research & Development: Fundamental material for method development and exploring new fluorination chemistry in academic and industrial R&D laboratories.

Basic Information

Product Name	2-Fluoro-5-Methylbenzoic Acid
CAS No.	321-12-0
Molecular Formula	C8H7FO2
Molecular Weight	154.14 g/mol
Synonyms	5-Methyl-2-fluorobenzoic Acid; 2-Fluoro-5-methylbenzoic Acid; 2-Fluoro-5-toluic Acid; 5-Methyl-2-fluorobenzoic Acid; Benzoic acid, 2-fluoro-5-methyl-; 2-Fluoro-p-toluic Acid; α-Fluoro-5-methylbenzoic Acid; 321-12-0 (CAS)
EINECS	Contact for details

Quality Control

Our 2-Fluoro-5-Methylbenzoic Acid is manufactured under a strict quality management system. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment aligns with cGMP principles where applicable, ensuring reliability for your critical synthesis processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Melting Point	158°C - 162°C
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals (as Pb)	≤20 ppm
Related Substances (HPLC)	Total impurities ≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.