Description

4-Nitro-3-(trifluoromethyl)benzoic acid is a versatile aromatic carboxylic acid derivative, distinguished by its nitro and trifluoromethyl substituents. This compound is a critical high-purity building block in advanced organic synthesis, valued for its ability to introduce both electron-withdrawing and fluorine-containing motifs into target molecules. It is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and material science industries who require reliable, high-quality intermediates for developing active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly those targeting specific enzyme inhibition or requiring fluorinated structures for metabolic stability.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and pesticides, where the trifluoromethyl group enhances biological activity and environmental persistence.
• Liquid Crystal & OLED Material Precursor: Serves as a starting material for synthesizing fluorinated aromatic cores used in electronic display technologies and organic light-emitting diodes.
• Polymer & Resin Modifier: Incorporated into polymer chains to alter physical properties such as thermal stability, chemical resistance, and solubility.
• Organic Synthesis Reagent: A versatile reagent for constructing complex aromatic systems in academic research and industrial process development.
• Dye & Pigment Intermediate: Used in the synthesis of specialized dyes and pigments where nitro and fluorine groups influence color and fastness properties.

Basic Information

Product Name	4-Nitro-3-(trifluoromethyl)benzoic Acid
CAS No.	320-38-7
Molecular Formula	C8H4F3NO4
Molecular Weight	235.12 g/mol
Synonyms	3-(Trifluoromethyl)-4-nitrobenzoic acid; 4-Nitro-3-trifluoromethylbenzoic acid; Benzoic acid, 4-nitro-3-(trifluoromethyl)-; 4-Nitro-α,α,α-trifluoro-m-toluic acid; 2-Nitro-5-carboxybenzotrifluoride; NSC 404082; 4-Nitro-3-trifluoromethyl-benzoic acid
EINECS	Contact for details

Quality Control

Our 4-Nitro-3-(trifluoromethyl)benzoic acid is produced under a strict quality management system. Each batch undergoes rigorous analytical testing including HPLC, NMR, and IR spectroscopy to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment supports applications requiring compliance with ICH guidelines and cGMP standards for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. The product is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	158 - 162 °C
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.