Description

4-Hydroxy-2-(Trifluoromethyl)Benzoic Acid is a versatile trifluoromethylated aromatic building block prized for its unique combination of a carboxylic acid and a phenolic hydroxyl group. This structure makes it a critical intermediate for synthesizing advanced molecules with enhanced biological activity and physicochemical properties. It is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced material sectors seeking to incorporate fluorine chemistry for product innovation.

Application

• Pharmaceutical Intermediate: Key synthon for the development of active pharmaceutical ingredients (APIs), particularly in non-steroidal anti-inflammatory drugs (NSAIDs) and other therapeutics where the trifluoromethyl group improves metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and pesticides, where the fluorine atoms contribute to increased lipophilicity and membrane permeability.
• Liquid Crystal & OLED Material Precursor: Serves as a building block for fluorine-containing monomers and polymers used in electronic displays and organic light-emitting diodes due to its electronic properties.
• Coordination Chemistry & Ligand Design: The bifunctional acid and phenol groups allow it to act as a chelating ligand for metal complexes in catalysis and material science.
• Advanced Polymer Modification: Incorporated into polymer backbones to impart special characteristics like chemical resistance, thermal stability, or specific surface properties.
• Research & Development: A valuable compound for medicinal chemistry and chemical biology research in exploring new structure-activity relationships.

Basic Information

Product Name	4-Hydroxy-2-(Trifluoromethyl)Benzoic Acid
CAS No.	320-32-1
Molecular Formula	C8H5F3O3
Molecular Weight	206.12 g/mol
Synonyms	2-(Trifluoromethyl)-4-hydroxybenzoic acid; 4-Hydroxy-2-(trifluoromethyl)benzoic acid; 2-Trifluoromethyl-4-hydroxybenzoic acid; Benzoic acid, 4-hydroxy-2-(trifluoromethyl)-; 4-Hydroxy-α,α,α-trifluoro-o-toluic acid; α,α,α-Trifluoro-4-hydroxy-o-toluic acid; 4-Carboxy-3-(trifluoromethyl)phenol
EINECS	206-274-0

Quality Control

Our 4-Hydroxy-2-(Trifluoromethyl)Benzoic Acid is manufactured under a strict quality management system. Every batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for fine chemical synthesis. Certificates of Analysis (COA) detailing all specifications are available upon request to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Keep away from incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.