Description

Clomipramine is a tricyclic dibenzazepine-class compound, primarily recognized for its role as a potent serotonin reuptake inhibitor. This high-purity active pharmaceutical ingredient (API) is critical for ensuring the efficacy and consistency of finished pharmaceutical formulations. It is essential for manufacturers in the global pharmaceutical sector developing treatments for obsessive-compulsive disorder and major depressive disorders, where precise chemical composition is paramount for therapeutic outcomes.

Application

• Pharmaceutical API: Primary use as the active ingredient in the manufacture of antidepressant and anti-obsessional medications.
• Reference Standard: Serves as a high-purity analytical standard in quality control laboratories for method development and validation.
• Research & Development: Utilized in preclinical and clinical studies within neuropharmacology to investigate mechanisms of serotonin reuptake inhibition.
• Formulation Development: Used in the development of various dosage forms, including tablets and capsules, requiring a reliable and consistent API source.

Basic Information

Product Name	Clomipramine
CAS No.	303-49-1
Molecular Formula	C19H23ClN2
Molecular Weight	314.85 g/mol
Synonyms	3-Chloro-5-[3-(dimethylamino)propyl]-10,11-dihydro-5H-dibenz[b,f]azepine; Clomipramine Hydrochloride (salt form); Anafranil; Chlorimipramine; G-34586; Hydiphen; Maronil
EINECS	206-137-6

Quality Control

Our Clomipramine is manufactured and tested under a strict quality management system. Each batch undergoes comprehensive analytical testing to ensure it meets stringent specifications for identity, purity, and potency, aligning with major pharmacopeial standards. A detailed Certificate of Analysis (COA), including results for assay and related substances, is provided with every shipment to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Individual impurity: ≤ 0.5% Total impurities: ≤ 1.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.